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Applied Sciences
Volume 11
Issue 11
10.3390/app11115192
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Review

The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

by
Roberta Angioi
,
Aoife Morrin
and
Blánaid White
*
School of Chemical Sciences, National Centre for Sensor Research, DCU Water Institute, Dublin City University, D09 V209 Dublin, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Daniel Severus Dezmirean
Appl. Sci. 2021, 11(11), 5192; https://doi.org/10.3390/app11115192
Received: 20 May 2021 / Revised: 29 May 2021 / Accepted: 30 May 2021 / Published: 3 June 2021
(This article belongs to the Special Issue Chemical Composition, Properties and Applications of Honey)
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Abstract

Honey is a honey-bee product obtained mainly by the enzymatic processing of nectar from a variety of plants, which leads to the wide range of colours and flavours available on the market. These organoleptic and nutritional features are influenced by the chemical composition, which in turn depends on the botanical origin. Bioactive compounds account for honey beneficial activity in medical applications, which explains the extensive use of honey in ethno-pharmacology since antiquity, from cough remedies to dermatological treatments. Wound healing is one of the main therapeutic uses of honey, and various design options in pharmaceutical technology such as smart delivery systems and advanced dressings are currently being developed to potentiate honey’s valuable properties for better performance and improved final outcome. In this review, we will focus on the latest research that discloses crucial factors in determining what properties are most beneficial when considering honey as a medicinal product. We will present the most recent updates on the possible mechanisms responsible for the exceptional effects of this ageless therapeutical remedy on skin repair. Furthermore, the state-of-the-art in application techniques (incorporation into scaffolds as an alternative to direct administration) used to enhance honey-mediated wound-healing properties are explored. View Full-Text
Keywords: honey; antioxidant; antibacterial; anti-inflammatory; polyphenolics; skin; healing; hydrogels honey; antioxidant; antibacterial; anti-inflammatory; polyphenolics; skin; healing; hydrogels
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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MDPI and ACS Style

Angioi, R.; Morrin, A.; White, B. The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques. Appl. Sci. 2021, 11, 5192. https://doi.org/10.3390/app11115192

AMA Style

Angioi R, Morrin A, White B. The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques. Applied Sciences. 2021; 11(11):5192. https://doi.org/10.3390/app11115192

Chicago/Turabian Style

Angioi, Roberta, Aoife Morrin, and Blánaid White. 2021. "The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques" Applied Sciences 11, no. 11: 5192. https://doi.org/10.3390/app11115192

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