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Review

Mini-Review: Potential of Diatom-Derived Silica for Biomedical Applications

1
Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
2
Department of Marine Microbiology and Biogeochemistry (MMB), Netherland Institute for Sea Research (NIOZ), Landsdiep 4, 1793 AB Texel, The Netherlands
*
Authors to whom correspondence should be addressed.
Academic Editor: Leonel Pereira
Appl. Sci. 2021, 11(10), 4533; https://doi.org/10.3390/app11104533
Received: 31 March 2021 / Revised: 12 May 2021 / Accepted: 14 May 2021 / Published: 16 May 2021
(This article belongs to the Special Issue Drugs from Marine Sources)
Diatoms are unicellular eukaryotic microalgae widely distributed in aquatic environments, possessing a porous silica cell wall known as frustule. Diatom frustules are considered as a sustainable source for several industrial applications because of their high biocompatibility and the easiness of surface functionalisation, which make frustules suitable for regenerative medicine and as drug carriers. Frustules are made of hydrated silica, and can be extracted and purified both from living and fossil diatoms using acid treatments or high temperatures. Biosilica frustules have proved to be suitable for biomedical applications, but, unfortunately, they are not officially recognised as safe by governmental food and medical agencies yet. In the present review, we highlight the frustule formation process, the most common purification techniques, as well as advantages and bottlenecks related to the employment of diatom-derived silica for medical purposes, suggesting possible solutions for a large-scale biosilica production. View Full-Text
Keywords: biosilica; diatom frustule; sustainable production; drug delivery biosilica; diatom frustule; sustainable production; drug delivery
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MDPI and ACS Style

Sardo, A.; Orefice, I.; Balzano, S.; Barra, L.; Romano, G. Mini-Review: Potential of Diatom-Derived Silica for Biomedical Applications. Appl. Sci. 2021, 11, 4533. https://doi.org/10.3390/app11104533

AMA Style

Sardo A, Orefice I, Balzano S, Barra L, Romano G. Mini-Review: Potential of Diatom-Derived Silica for Biomedical Applications. Applied Sciences. 2021; 11(10):4533. https://doi.org/10.3390/app11104533

Chicago/Turabian Style

Sardo, Angela, Ida Orefice, Sergio Balzano, Lucia Barra, and Giovanna Romano. 2021. "Mini-Review: Potential of Diatom-Derived Silica for Biomedical Applications" Applied Sciences 11, no. 10: 4533. https://doi.org/10.3390/app11104533

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