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Review

Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

1
Department of Biochemistry, Microbiology, Genetics and Cell Biology, Facultad de Farmacia, Universidad de La Laguna, 38206 San Cristóbal de La Laguna, Spain
2
AbbVie Deutschland GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, Germany
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Faculty of Sciences and Technology, University of Azores, 9500-321 Ponta Delgada, Portugal
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Research Institution “Chinese-Tajik Innovation Center for Natural Products”, Academy of Sciences of the Republic of Tajikistan, Ayni 299/2, Dushanbe 734063, Tajikistan
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cE3c—Centre for Ecology, Evolution and Environmental Changes/Azorean Biodiversity Group & Faculty of Sciences and Technology, University of Azores, Rua Mãe de Deus, 9500-321 Ponta Delgada, Portugal
6
LAQV-REQUIMTE, University of Aveiro, 3810-193 Aveiro, Portugal
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2020, 10(9), 3001; https://doi.org/10.3390/app10093001
Received: 25 March 2020 / Revised: 17 April 2020 / Accepted: 19 April 2020 / Published: 25 April 2020
(This article belongs to the Special Issue Biological Activity and Applications of Natural Compounds)
Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are already commercially available, such as artemisinin. Here the most recent and impactful results of in vivo, preclinical and clinical studies involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) are presented and discussed, along with some of their derivatives. In the authors’ opinion, these compounds have been neglected compared to others, although they could be of great use in developing important new pharmaceutical products. The selected sesquiterpenes show promising anticancer and anti-inflammatory effects, acting on various targets. Moreover, they exhibit antifungal, anxiolytic, analgesic, and antitrypanosomal activities. Several studies discussed here clearly show the potential that some of them have in combination therapy, as sensitizing agents to facilitate and enhance the action of drugs in clinical use. The derivatives show greater pharmacological value since they have better pharmacokinetics, stability, potency, and/or selectivity. All these natural terpenoids and their derivatives exhibit properties that invite further research by the scientific community. View Full-Text
Keywords: Asteraceae; sesquiterpene lactones; alantolactone; arglabin; parthenolide; thapsigargin; in vivo study; anticancer; anti-inflammatory Asteraceae; sesquiterpene lactones; alantolactone; arglabin; parthenolide; thapsigargin; in vivo study; anticancer; anti-inflammatory
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MDPI and ACS Style

Moujir, L.; Callies, O.; Sousa, P.M.C.; Sharopov, F.; Seca, A.M.L. Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases. Appl. Sci. 2020, 10, 3001. https://doi.org/10.3390/app10093001

AMA Style

Moujir L, Callies O, Sousa PMC, Sharopov F, Seca AML. Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases. Applied Sciences. 2020; 10(9):3001. https://doi.org/10.3390/app10093001

Chicago/Turabian Style

Moujir, Laila, Oliver Callies, Pedro M.C. Sousa, Farukh Sharopov, and Ana M.L. Seca 2020. "Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases" Applied Sciences 10, no. 9: 3001. https://doi.org/10.3390/app10093001

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