Platelet Aggregation Inhibitors and Anticoagulants Delay Surgery for Hip Fractures

Suciu, Oana; Deleanu, Bogdan; Haragus, Horia; Hoinoiu, Teodora; Tudoran, Cristina; Todor, Adrian; Ghiorghitoiu, Andrei; Velimirovici, Nevena; Onofrei, Roxana Ramona

doi:10.3390/app10238617

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Platelet Aggregation Inhibitors and Anticoagulants Delay Surgery for Hip Fractures

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Roxana Ramona Onofrei

Department of Rehabilitation, “Victor Babes” University of Medicine and Pharmacy, No 2 Eftimie Murgu Square, 300041 Timisoara, Romania

Department of Orthopedics and Trauma, “Victor Babes” University of Medicine and Pharmacy, No 2 Eftimie Murgu Square, 300041 Timisoara, Romania

Department of Clinical Practical Skils, “Victor Babes” University of Medicine and Pharmacy, No 2 Eftimie Murgu Square, 300041 Timisoara, Romania

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2nd Department of Internal Medicine, “Victor Babes” University of Medicine and Pharmacy, No 2 Eftimie Murgu Square, 300041 Timisoara, Romania

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Department of Orthopedics, Traumatology and Pediatric Orthopedics, “Iuliu Hatieganu” University of Medicine and Pharmacy, No 8 Victor Babes Str, 400000 Cluj-Napoca, Romania

Author to whom correspondence should be addressed.

Appl. Sci. 2020, 10(23), 8617; https://doi.org/10.3390/app10238617

Received: 25 October 2020 / Revised: 28 November 2020 / Accepted: 30 November 2020 / Published: 2 December 2020

(This article belongs to the Special Issue New Trends in Functional and Multifunctional Advanced Materials)

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Abstract

Background: we aimed to analyze the influence of antithrombotic medication in delaying surgery for fragility hip fractures; Method: a total of 312 consecutive hip fracture cases over 55 years who underwent surgery in our Orthopedic Clinic; Results: of these, 90 patients received chronic antithrombotic medication. There were no differences between the medicated group and controls (n = 222) regarding age, gender, type of fracture and haemoglobin at admittance. However, median time to surgery was significantly longer in the medicated group: 4(3–6) days compared to 2(1–4) (p < 0.0001). By type of medication, time to surgery was: 3(1–4) days for acetylsalicylic acid (n = 44), 6(5.25–7.75) days for clopidogrel (n = 15), 4.5(4–7) days for acenocoumarin (n = 18) and 5(4–7.25) days for novel direct oral anticoagulants (n = 13). The Charlson comorbidity index was significantly higher in the medicated group: 5 [4–5] versus 4 [3–5]. There were no differences in transfusions except for fresh frozen plasma, which was administered more in the medicated patients; Conclusions: the prevalence of platelet aggregation inhibitors and anticoagulant use among fragility hip fracture patients is high, with almost a third using some form of antithrombotic medication. This may significantly lengthen time to surgery. View Full-Text

Keywords: aged; anesthesia/methods; anticoagulants; hip fractures/drug therapy; hip fractures/surgery; length of stay; platelet aggregation inhibitors; time to treatment

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Suciu, O.; Deleanu, B.; Haragus, H.; Hoinoiu, T.; Tudoran, C.; Todor, A.; Ghiorghitoiu, A.; Velimirovici, N.; Onofrei, R.R. Platelet Aggregation Inhibitors and Anticoagulants Delay Surgery for Hip Fractures. Appl. Sci. 2020, 10, 8617. https://doi.org/10.3390/app10238617

AMA Style

Suciu O, Deleanu B, Haragus H, Hoinoiu T, Tudoran C, Todor A, Ghiorghitoiu A, Velimirovici N, Onofrei RR. Platelet Aggregation Inhibitors and Anticoagulants Delay Surgery for Hip Fractures. Applied Sciences. 2020; 10(23):8617. https://doi.org/10.3390/app10238617

Chicago/Turabian Style

Suciu, Oana, Bogdan Deleanu, Horia Haragus, Teodora Hoinoiu, Cristina Tudoran, Adrian Todor, Andrei Ghiorghitoiu, Nevena Velimirovici, and Roxana R. Onofrei. 2020. "Platelet Aggregation Inhibitors and Anticoagulants Delay Surgery for Hip Fractures" Applied Sciences 10, no. 23: 8617. https://doi.org/10.3390/app10238617

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Platelet Aggregation Inhibitors and Anticoagulants Delay Surgery for Hip Fractures

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