Next Article in Journal
Human Height Estimation by Color Deep Learning and Depth 3D Conversion
Previous Article in Journal
Theranostic Nanoplatforms of Thiolated Reduced Graphene Oxide Nanosheets and Gold Nanoparticles
Previous Article in Special Issue
Micro-Structured Patches for Dermal Regeneration Obtained via Electrophoretic Replica Deposition
Article

Incorporation of Bioactive Glasses Containing Mg, Sr, and Zn in Electrospun PCL Fibers by Using Benign Solvents

1
Dipartimento di Ingegneria Enzo Ferrari, Università degli Studi di Modena e Reggio Emilia, Via P. Vivarelli 10, 41125 Modena, Italy
2
Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstr. 6, 91058 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(16), 5530; https://doi.org/10.3390/app10165530
Received: 4 July 2020 / Revised: 4 August 2020 / Accepted: 7 August 2020 / Published: 10 August 2020
Poly(ε-caprolactone) (PCL) and PCL/bioactive glass composite fiber mats were produced by electrospinning technique. To improve cell adhesion and proliferation (i) 45S5, (ii) a bioactive glass containing strontium and magnesium oxides, and (iii) a bioactive glass containing zinc oxide were separately added to the starting PCL solution before electrospinning. A good incorporation of bioactive glass particles in PCL electrospun mats was confirmed by SEM and FTIR analyses. Bioactivity was evaluated by immersion of PCL mats and PCL/bioactive glass electrospun fiber mats in simulated body fluid (SBF). Bone murine stromal cells (ST-2) were employed in WST-8 assay to assess cell viability, cell morphology, and proliferation. The results showed that the presence of bioactive glass particles in the fibers enhances cell adhesion and proliferation compared to neat PCL mats. Furthermore, PCL/bioactive glass electrospun mats showed higher wound-healing rate (measured as cell migration rate) in vitro compared to neat PCL electrospun mats. Therefore, the characteristics of the PCL matrix combined with biological properties of bioactive glasses make PCL/bioactive glass composite ideal candidate for biomedical application. View Full-Text
Keywords: PCL; bioactive glass; composite; electrospinning; wound healing PCL; bioactive glass; composite; electrospinning; wound healing
Show Figures

Figure 1

MDPI and ACS Style

Sergi, R.; Cannillo, V.; Boccaccini, A.R.; Liverani, L. Incorporation of Bioactive Glasses Containing Mg, Sr, and Zn in Electrospun PCL Fibers by Using Benign Solvents. Appl. Sci. 2020, 10, 5530. https://doi.org/10.3390/app10165530

AMA Style

Sergi R, Cannillo V, Boccaccini AR, Liverani L. Incorporation of Bioactive Glasses Containing Mg, Sr, and Zn in Electrospun PCL Fibers by Using Benign Solvents. Applied Sciences. 2020; 10(16):5530. https://doi.org/10.3390/app10165530

Chicago/Turabian Style

Sergi, Rachele, Valeria Cannillo, Aldo R. Boccaccini, and Liliana Liverani. 2020. "Incorporation of Bioactive Glasses Containing Mg, Sr, and Zn in Electrospun PCL Fibers by Using Benign Solvents" Applied Sciences 10, no. 16: 5530. https://doi.org/10.3390/app10165530

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop