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Review

Doped Zinc Oxide Nanoparticles: Synthesis, Characterization and Potential Use in Nanomedicine

Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy
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Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(15), 5194; https://doi.org/10.3390/app10155194
Received: 18 June 2020 / Revised: 17 July 2020 / Accepted: 20 July 2020 / Published: 28 July 2020
Smart nanoparticles for medical applications have gathered considerable attention due to an improved biocompatibility and multifunctional properties useful in several applications, including advanced drug delivery systems, nanotheranostics and in vivo imaging. Among nanomaterials, zinc oxide nanoparticles (ZnO NPs) were deeply investigated due to their peculiar physical and chemical properties. The large surface to volume ratio, coupled with a reduced size, antimicrobial activity, photocatalytic and semiconducting properties, allowed the use of ZnO NPs as anticancer drugs in new generation physical therapies, nanoantibiotics and osteoinductive agents for bone tissue regeneration. However, ZnO NPs also show a limited stability in biological environments and unpredictable cytotoxic effects thereof. To overcome the abovementioned limitations and further extend the use of ZnO NPs in nanomedicine, doping seems to represent a promising solution. This review covers the main achievements in the use of doped ZnO NPs for nanomedicine applications. Sol-gel, as well as hydrothermal and combustion methods are largely employed to prepare ZnO NPs doped with rare earth and transition metal elements. For both dopant typologies, biomedical applications were demonstrated, such as enhanced antimicrobial activities and contrast imaging properties, along with an improved biocompatibility and stability of the colloidal ZnO NPs in biological media. The obtained results confirm that the doping of ZnO NPs represents a valuable tool to improve the corresponding biomedical properties with respect to the undoped counterpart, and also suggest that a new application of ZnO NPs in nanomedicine can be envisioned. View Full-Text
Keywords: zinc oxide nanoparticles; doped ZnO; rare earth; transition metals; bioimaging; drug delivery; theranostics; antibacterial properties zinc oxide nanoparticles; doped ZnO; rare earth; transition metals; bioimaging; drug delivery; theranostics; antibacterial properties
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MDPI and ACS Style

Carofiglio, M.; Barui, S.; Cauda, V.; Laurenti, M. Doped Zinc Oxide Nanoparticles: Synthesis, Characterization and Potential Use in Nanomedicine. Appl. Sci. 2020, 10, 5194. https://doi.org/10.3390/app10155194

AMA Style

Carofiglio M, Barui S, Cauda V, Laurenti M. Doped Zinc Oxide Nanoparticles: Synthesis, Characterization and Potential Use in Nanomedicine. Applied Sciences. 2020; 10(15):5194. https://doi.org/10.3390/app10155194

Chicago/Turabian Style

Carofiglio, Marco, Sugata Barui, Valentina Cauda, and Marco Laurenti. 2020. "Doped Zinc Oxide Nanoparticles: Synthesis, Characterization and Potential Use in Nanomedicine" Applied Sciences 10, no. 15: 5194. https://doi.org/10.3390/app10155194

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