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Article

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro

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Department of Physics, Ariel University, Ariel 40700, Israel
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Department of Molecular Biology, Ariel University, Ariel 40700, Israel
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Department of Electrical & Electronic Engineering, Ariel University, Ariel 40700, Israel
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Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(14), 4813; https://doi.org/10.3390/app10144813
Received: 16 May 2020 / Revised: 14 June 2020 / Accepted: 6 July 2020 / Published: 13 July 2020
(This article belongs to the Section Applied Physics)
Therapeutically effective treatments of cancer are limited. To calibrate the efficiency of the novel technique we recently discovered to modulate cancer cell viability using tuned electromagnetic fields; H1299 human lung cancer cells were irradiated in a sweeping regime of W-band (75–105 GHz) millimeter waves (MMW) at 0.2 mW/cm2 (2 W/m2). Effects on cell morphology, cell death and senescence were examined and compared to that of non-tumorigenic MCF-10A human epithelial cells. MMW irradiation led to alterations of cell and nucleus morphology of H1299 cells, significantly increasing mortality and senescence over 14 days of observation. Extended irradiation of 10 min duration resulted in complete death of exposed H1299 cell population within two days, while healthy MCF-10A cells remained unaffected even after 16 min of irradiation under the same conditions. Irradiation effects were observed to be specific to MMW treated H1299 cells and absent in the control group of non-irradiated cells. MMW irradiation affected nuclear morphology of H1299 cells only and not of the immortalized MCF-10A cells. Irradiation with low intensity MMW shows an antitumor effect on H1299 lung cancer cells. This method provides a novel treatment modality enabling targeted specificity for various types of cancers. View Full-Text
Keywords: W-band (75–105 GHz) MMW; H1299 human lung cancer cells; non-tumorigenic MCF-10A human epithelial cells; in vitro W-band (75–105 GHz) MMW; H1299 human lung cancer cells; non-tumorigenic MCF-10A human epithelial cells; in vitro
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MDPI and ACS Style

Komoshvili, K.; Israel, K.; Levitan, J.; Yahalom, A.; Barbora, A.; Liberman-Aronov, S. W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro. Appl. Sci. 2020, 10, 4813. https://doi.org/10.3390/app10144813

AMA Style

Komoshvili K, Israel K, Levitan J, Yahalom A, Barbora A, Liberman-Aronov S. W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro. Applied Sciences. 2020; 10(14):4813. https://doi.org/10.3390/app10144813

Chicago/Turabian Style

Komoshvili, Konstantin, Katya Israel, Jacob Levitan, Asher Yahalom, Ayan Barbora, and Stella Liberman-Aronov. 2020. "W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro" Applied Sciences 10, no. 14: 4813. https://doi.org/10.3390/app10144813

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