Numerical Analysis of Human Cancer Therapy Using Microwave Ablation
Round 1
Reviewer 1 Report
Please find in the attachment some suggestions/comments to your interesting paper.
Comments for author File: 
Comments.pdf
Author Response
Journal: Applied Sciences
Manuscript ID: applsci-665217
Title: " Numerical analysis of human cancer therapy using microwave ablation"
Authors: Marwa Selmi, Abdul Aziz Bin Dukhyil, Hafedh Belmabrouk,
Acknowledgement
The authors would like to express their sincere appreciation for the valuable suggestions and informative comments provided by the reviewers of the manuscript. We also would like to express our gratitude to the Editor.
We have edited the manuscript with more accuracy, replaced the inappropriate words and modified the manuscript accordingly. The detailed corrections are listed below point by point.
The corrected sentences/words in the text are reported by red color.
Author Response File: Author Response.pdf
Reviewer 2 Report
The manuscript entitled ‘Numerical analysis of human cancer therapy using microwave ablation’ addresses a topic of interest in a clear and concise style.
I have one issue that I think need to be addressed before this paper can be considered for publication:
Could you please explain which temperature and power are the best to kill liver cancer cells? In the abstract there is written that the temperature above 50oC may destroy healthy cells (for sure will do it), further power of 10 W can kill cells without healthy tissue. In results part you wrote that max. temp produced by MW power P=10 W is estimated to 86o Is it possible to get the power of 10 W and temperature below 50oC (for human 42oC maximum)? Probably not all the tumor will be heated…………….What do you think about future application in humans? Would it be possible to get satisfied results in a certain compromise?Author Response
Journal: Applied Sciences
Manuscript ID: applsci-665217
Title: " Numerical analysis of human cancer therapy using microwave ablation"
Authors: Marwa Selmi, Abdul Aziz Bin Dukhyil, Hafedh Belmabrouk,
Acknowledgement
The authors would like to express their sincere appreciation for the valuable suggestions and informative comments provided by the reviewers of the manuscript. We also would like to express our gratitude to the Editor.
We have edited the manuscript with more accuracy, replaced the inappropriate words and modified the manuscript accordingly. The detailed corrections are listed below point by point.
The corrected sentences/words in the text are reported by red color.
Point 1:
Comments and Suggestions for Authors
The manuscript entitled ‘Numerical analysis of human cancer therapy using microwave ablation’ addresses a topic of interest in a clear and concise style.
I have one issue that I think need to be addressed before this paper can be considered for publication:
Could you please explain which temperature and power are the best to kill liver cancer cells? In the abstract there is written that the temperature above 50 °C may destroy healthy cells (for sure will do it), further power of 10 W can kill cells without healthy tissue. In results part you wrote that max. temp produced by MW power P=10 W is estimated to 86 °C Is it possible to get the power of 10 W and temperature below 50 °C (for human 42 °C maximum)? Probably not all the tumor will be heated…………….What do you think about future application in humans? Would it be possible to get satisfied results in a certain compromise?
Response 1: Please provide your response for Point 1. (in red) and this explanation was added in the manuscript
In our work, the maximum temperature produced by microwave power is estimated to 86°C, i.e. the rise temperature . Further, based on Fig.11, it is found that the complete tumor necrosis has been reached only in the case for the position r=0.005 mm away from the antenna, and the time required for complete necrosis has been found to be 160 s for . This power is suitable for small tumor size. The analysis of this study serves as an essential base for the microwave ablation process and can be used as a guideline for the practical treatment. Nevertheless, more care must be taken and a certain compromise should be achieved to kill a maximal part of the tumor while conserving the healthy cells.
A future work will be performed taking into account the size of tumor with the applied input microwave power using a programmable temperature-controlled by incorporation the proportional-integral-derivative (PID) to better control the temperature distribution.
Author Response File: Author Response.pdf
