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Article

Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa

1
IRCCS Istituto delle Scienze Neurologiche di Bologna, Centro Regionale per i Disturbi della Nutrizione e dell’Alimentazione in Età Evolutiva, U.O. di Neuropsichiatria dell’Età Pediatrica, 40138 Bologna, Italy
2
Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Università di Bologna, 40138 Bologna, Italy
3
Oasi Research Institute-IRCCS, 94018 Troina, Italy
4
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PromISE), University of Palermo, 90128 Palermo, Italy
5
Department of Psychology, Educational Science and Human Movement, University of Palermo, 90128 Palermo, Italy
*
Author to whom correspondence should be addressed.
These authors equally contributed to this work.
Academic Editor: Amanda Sainsbury-Salis
Behav. Sci. 2021, 11(12), 173; https://doi.org/10.3390/bs11120173
Received: 10 November 2021 / Revised: 6 December 2021 / Accepted: 7 December 2021 / Published: 10 December 2021
Clotiapine is an atypical antipsychotic indicated for the management of a series of acute psychotic disorders. The current literature lacks evidence concerning the tolerability and clinical use of this drug in the management of individuals with anorexia nervosa (AN). In this study, we report two cases of adolescents with AN, treated with clotiapine. The reason for the administration of clotiapine was, for both patients, the manifestation of bizarre delusions concerning food and calories. Patient 1 presented a presyncope after the first dose of clotiapine, and treatment was rapidly discontinued. Patient 2 was treated with clotiapine for 9 months; doses were titrated from 20 mg/day to 70 mg/day, with an improvement in the reported delusions, which also enhanced compliance with psychological and nutritional interventions. EKG, QTc, white blood count, and red blood count were not relevantly influenced by the introduction of clotiapine in either patient. No extrapyramidal effect was documented. These reports stress the need for further studies assessing the tolerability and potential effect of clotiapine in treating adolescents with AN and delusional symptomatology. View Full-Text
Keywords: clotiapine; anorexia nervosa; eating disorders; adolescents; inpatient treatment; antipsychotics clotiapine; anorexia nervosa; eating disorders; adolescents; inpatient treatment; antipsychotics
MDPI and ACS Style

Pruccoli, J.; Leone, G.J.; Di Sarno, C.; Vetri, L.; Quatrosi, G.; Roccella, M.; Parmeggiani, A. Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa. Behav. Sci. 2021, 11, 173. https://doi.org/10.3390/bs11120173

AMA Style

Pruccoli J, Leone GJ, Di Sarno C, Vetri L, Quatrosi G, Roccella M, Parmeggiani A. Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa. Behavioral Sciences. 2021; 11(12):173. https://doi.org/10.3390/bs11120173

Chicago/Turabian Style

Pruccoli, Jacopo, Giulia J. Leone, Cristina Di Sarno, Luigi Vetri, Giuseppe Quatrosi, Michele Roccella, and Antonia Parmeggiani. 2021. "Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa" Behavioral Sciences 11, no. 12: 173. https://doi.org/10.3390/bs11120173

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