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Surgical Strategies to Promote Cutaneous Healing

Burn Injury: Mechanisms of Keratinocyte Cell Death

Department of Plastic Surgery, Hand and Burn Surgery, Burn Center, Rhein Maas Klinikum, 52146 Wuerselen, Germany
Plastic Surgery and Burn Unit, Fakeeh Care & Fakeeh College of Medical Sciences, P.O. Box 2537, Jeddah 21461, Saudi Arabia
Author to whom correspondence should be addressed.
Academic Editors: Heiko Sorg and Antoni Torres
Med. Sci. 2021, 9(3), 51;
Received: 23 May 2021 / Revised: 27 June 2021 / Accepted: 7 July 2021 / Published: 16 July 2021
(This article belongs to the Special Issue Skin Wound Healing)
Cutaneous burn injury is associated with epidermal loss in the zone of coagulation zone and delayed tissue loss in the zone of stasis. Thus, thermal stress can trigger both necrosis and regulated cell death (RCD) or apoptosis. Experimental in vitro and in vivo work has clearly demonstrated apoptotic events of thermally injured keratinocytes that are accompanied by morphological and biochemical markers of regulated cell death. However, in vivo data for the different pathways of regulated cell death are sparse. In vitro experiments with heat-stressed human keratinocytes have demonstrated death receptor involvement (extrinsic apoptosis), calcium influx, and disruption of mitochondrial membrane potential (intrinsic apoptosis) in regulated cell death. In addition, caspase-independent pathways have been suggested in regulated cell death. Keratinocyte heat stress leads to reduced proliferation, possibly as a result of reduced keratinocyte adhesion (anoikis) or oncogene involvement. Understanding the underlying mechanisms of RCD and the skin’s responses to thermal stress may lead to improved strategies for treating cutaneous burn trauma. View Full-Text
Keywords: burn; wound; keratinocyte; apoptosis; cell death; review burn; wound; keratinocyte; apoptosis; cell death; review
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MDPI and ACS Style

Rennekampff, H.-O.; Alharbi, Z. Burn Injury: Mechanisms of Keratinocyte Cell Death. Med. Sci. 2021, 9, 51.

AMA Style

Rennekampff H-O, Alharbi Z. Burn Injury: Mechanisms of Keratinocyte Cell Death. Medical Sciences. 2021; 9(3):51.

Chicago/Turabian Style

Rennekampff, Hans-Oliver, and Ziyad Alharbi. 2021. "Burn Injury: Mechanisms of Keratinocyte Cell Death" Medical Sciences 9, no. 3: 51.

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