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Article

Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis

1
Scientific Research Institute “CRSC”, 20100 Milan, Italy
2
Scientific Association “ARSS”, 00100 Rome, Italy
3
Department of Pharmacology, Kabardine University, 101000 Nalchik, Russia
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Department of Neuroscience and Rehabilitation, University of Ferrara, 44100 Ferrara, Italy
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Department of Psychology and Sports Science, Giessen Justus, Liebig University Gießen, 35398 Gießen, Germany
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Department of Health Engineering, Université Européenne de Bruxelles Jean Monnet, Schaerbeek, 1030 Brussels, Belgium
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Department of Physics, University of Tor Vergata, 00100 Rome, Italy
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Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44100 Ferrara, Italy
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Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00100 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Antoni Torres
Med. Sci. 2021, 9(3), 52; https://doi.org/10.3390/medsci9030052
Received: 28 April 2021 / Revised: 12 July 2021 / Accepted: 14 July 2021 / Published: 20 July 2021
(This article belongs to the Special Issue Feature Papers in Medical Sciences)
Despite recent advances in immune-modulatory drugs, pharmacological therapies have been proven ineffective in severe presentations of multiple sclerosis (MS), including secondary progressive MS. At present, therapeutic interventions’ performance is primarily focused on ameliorating symptoms to improve the patient’s quality of life (QOL). Among complementary treatments, nutrition has been considered a decisive factor to control symptoms and enhance the wellness of MS patients. Although no special diets are associated with MS, the impact of diet and dietary supplements on the course of progressive forms of the disease has been studied during the last few years. Fatigue is among the most common and disabling symptoms reported by MS patients. Fatigue has been defined in the Multiple Sclerosis Council for Clinical Practice Guidelines (MSCCPG, 1998) as a “subjective lack of physical and/or mental energy that the individual perceives as an interference with habitual and desired activities”. This study aimed to compare the psychometric functioning of the “Fatigue Severity Scale” (FSS) and the “Modified Fatigue Impact Scale” (MFIS) in our sample of people with MS. Specifically, during chronic treatment, the change in these two parameters with two vitamin-rich dietary supplements (Citozym® and Ergozym®) was evaluated. The impact of these nutritional supplements revealed differences in antioxidant and anti-inflammatory parameters among the volunteers in the treatment group, with a subsequent improvement in fatigue. In conclusion, the results obtained have confirmed the effectiveness of complementary nutritional therapies, evaluated essentially based on hematological biomarkers, through which it is possible to act on disability to improve the QOL of MS patients. View Full-Text
Keywords: multiple sclerosis; fatigue; dietary supplements; vitamins; QOL multiple sclerosis; fatigue; dietary supplements; vitamins; QOL
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MDPI and ACS Style

Ferorelli, P.; Antonelli, F.; Shevchenko, A.; Mischiati, C.; Doepp, M.; Lenzi, S.; Borromeo, I.; Feriotto, G.; Beninati, S. Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis. Med. Sci. 2021, 9, 52. https://doi.org/10.3390/medsci9030052

AMA Style

Ferorelli P, Antonelli F, Shevchenko A, Mischiati C, Doepp M, Lenzi S, Borromeo I, Feriotto G, Beninati S. Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis. Medical Sciences. 2021; 9(3):52. https://doi.org/10.3390/medsci9030052

Chicago/Turabian Style

Ferorelli, Pasquale, Francesco Antonelli, Anna Shevchenko, Carlo Mischiati, Manfred Doepp, Stefano Lenzi, Ilaria Borromeo, Giordana Feriotto, and Simone Beninati. 2021. "Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis" Medical Sciences 9, no. 3: 52. https://doi.org/10.3390/medsci9030052

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