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Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study

1
Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan
2
Department of Breast Surgical Oncology, St. Luke’s International Hospital, 9-1 Akashicho, Chuo-ku, Tokyo 104-8560, Japan
3
Department of Biostatistics, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
4
Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Kentaro Inamura
Med. Sci. 2021, 9(3), 50; https://doi.org/10.3390/medsci9030050
Received: 27 May 2021 / Revised: 7 July 2021 / Accepted: 9 July 2021 / Published: 12 July 2021
(This article belongs to the Section Cancer and Cancer-Related Research)
Background: This study aimed to investigate the association between endocrine therapy and weight gain with a history of breast cancer. Methods: This was a retrospective cohort study. Recruited patients consisted of those receiving endocrine therapy and those not receiving endocrine therapy. Weight at diagnosis was collected from medical records, and current body mass was measured using a digital scale (time since diagnosis was 4.0 ± 1.9 years). Moreover, we measured current physical activity using an accelerometer and dietary intake using a validated questionnaire. The primary analysis was a t-test for the body-mass change after diagnosis between the two groups. Results: We recruited 300 patients and collected data from 292. Mean weight gain after diagnosis was 1.3 ± 3.9 kg, and the change in body mass of patients taking endocrine therapy (1.3 ± 4.0 kg) was not significantly different from that of patients not taking endocrine therapy (1.4 ± 3.8 kg, p = 0.92). There was no association of endocrine therapy, physical activity, and dietary intake with a 5% weight gain after adjusting confounding factors (e.g., breast cancer stage and chemotherapy). Conclusions: Caution is required with generalization because of sampling bias and ethnic differences. View Full-Text
Keywords: cancer survivors; body weight change; exercise; eating cancer survivors; body weight change; exercise; eating
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MDPI and ACS Style

Okumatsu, K.; Yamauchi, H.; Kotake, R.; Gosho, M.; Nakata, Y. Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study. Med. Sci. 2021, 9, 50. https://doi.org/10.3390/medsci9030050

AMA Style

Okumatsu K, Yamauchi H, Kotake R, Gosho M, Nakata Y. Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study. Medical Sciences. 2021; 9(3):50. https://doi.org/10.3390/medsci9030050

Chicago/Turabian Style

Okumatsu, Koki, Hideko Yamauchi, Rina Kotake, Masahiko Gosho, and Yoshio Nakata. 2021. "Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study" Medical Sciences 9, no. 3: 50. https://doi.org/10.3390/medsci9030050

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