Effectiveness of Physical Activity with Sports Scientist (PASS) Programme Among Patients with Non-Communicable Diseases in Primary Care: A Randomised Controlled Trial
Abstract
1. Introduction
2. Methods
2.1. Patient and Public Involvement
2.2. Equity, Diversity, and Inclusion
2.3. Study Design and Setting
2.4. Participants and Recruitment
2.5. Sample Size
2.6. Randomisation
2.7. Interventions
2.8. Outcomes
2.9. Data Collection
2.10. Study Assessments
2.11. Data Analysis
3. Results
3.1. Recruitment and Baseline Characteristics
3.2. Participant Flow Diagram and Outcome Measurements
3.3. Primary and Secondary Outcomes
3.4. Longitudinal Changes in Outcomes
4. Discussion
4.1. Clinical Implications
4.2. Limitations
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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| Characteristic | Total (n = 120) | Intervention (n = 60) | Control (n = 60) | p-Value |
|---|---|---|---|---|
| Age (median, IQR) [years] | 56.5 (50.0 to 62.0) | 55.5 (48.0 to 63.0) | 58.0 (52.0 to 61.0) | 0.670 † |
| Sex | 0.166 ‡ | |||
| Female (n, (%)) | 83 (69.2) | 45 (75.0) | 38 (63.3) | |
| Male (n, (%)) | 37 (30.8) | 15 (25.0) | 22 (36.7) | |
| NCDs | ||||
| T2DM (n, (%)) | 21 (17.5) | 11 (18.3) | 10 (16.7) | 0.810 ‡ |
| HT (n, (%)) | 41 (34.2) | 24 (40.0) | 17 (28.3) | 0.178 ‡ |
| DLP (n, (%)) | 117 (97.5) | 58 (96.7) | 59 (98.3) | 1.000 ‡ |
| MVPA (median, IQR) [min/week] | 0 (0 to 90) | 7.5 (0 to 90) | 0 (0 to 75) | 0.731 † |
| Outcome | Visit 1: Baseline (Month 0) | Visit 2: Follow-Up (Months 3–4) | Visit 3: End-Point (Months 6–8) | Visit 4: Continuing (Months 9–12) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Intervention | Control | p-Value | Intervention | Control | p-Value | Intervention | Control | p-Value | Intervention | Control | p-Value | |
| Loss to follow-up (n, (%)) | Allocation | 9 (15.0) | 11 (18.3) | 10 (16.7) | 7 (11.7) | 5 (8.3) | 8 (13.3) | |||||
| Number of participants for analysis | 60 | 60 | 60 | 60 | 60 | 60 | 60 | 60 | ||||
| Primary outcomes | ||||||||||||
| Meeting PA recommendations | ||||||||||||
| Aerobic (n, (%)) | 0 (0) | 0 (0) | 1.000 ‡ | 14 (23.3) | 4 (6.7) | 0.011 ‡ | 9 (15.0) | 9 (15.0) | 1.000 ‡ | 18 (30.0) | 16 (26.7) | 0.685 ‡ |
| Muscle-strengthening (n, (%)) | 0 (0) | 0 (0) | 1.000 ‡ | 19 (31.7) | 0 | <0.001 ‡ | 5 (8.3) | 4 (6.7) | 1.000 ‡ | 4 (6.7) | 3 (5.0) | 1.000 ‡ |
| Multicomponent (n, (%)) | 0 (0) | 1 (1.7) | 1.000 ‡ | 12 (20.0) | 0 | <0.001 ‡ | 2 (3.3) | 3 (5.0) | 1.000 ‡ | 2 (3.3) | 1 (1.7) | 1.000 ‡ |
| MVPA (median, IQR) [min/week] | 7.5 (0, 90) | 0 (0, 75) | 0.731 † | 90.0 (30.0, 120.0) | 60.0 (0, 92.5) | 0.040 † | 85.0 (0, 120.0) | 60.0 (27.5, 120.0) | 0.844 † | 90.0 (43.8, 150.0) | 90.0 (37.5, 142.5) | 0.475 † |
| Secondary outcomes | ||||||||||||
| Body composition | ||||||||||||
| Body weight (median, IQR) [kg] | 60.4 (52.0, 67.2) | 64.1 (56.9, 70.9) | 0.097 † | 61.6 (52.0, 67.4) | 63.8 (56.6, 71.8) | 0.127 † | 61.3 (52.1, 68.4) | 62.4 (56.5, 71.5) | 0.159 † | 60.9 (53.0, 67.7) | 63.8 (57.7, 71.8) | 0.105 † |
| Body mass index (median, IQR) [kg/m2] | 24.2 (22.2, 26.9) | 24.6 (22.8, 27.0) | 0.342 † | 24.2 (21.7, 27.1) | 24.5 (23.0, 27.1) | 0.388 † | 24.5 (22.0, 27.2) | 24.5 (22.8, 27.0) | 0.492 † | 24.4 (22.0, 27.0) | 24.6 (23.2, 26.6) | 0.446 † |
| Fat mass (median, IQR) [kg] | 18.4 (13.4, 25.2) | 19.1 (15.4, 22.9) | 0.650 † | 17.7 (13.8, 25.1) | 19.4 (15.4, 22.9) | 0.635 † | 18.2 (13.5, 25.4) | 19.4 (15.3, 23.0) | 0.616 † | 19.2 (13.9, 25.4) | 19.9 (15.7, 23.8) | 0.650 † |
| Percentage of fat (median, IQR) [%] | 31.0 (24.6, 37.6) | 31.2 (24.1, 36.4) | 0.605 † | 31.0 (25.6, 36.8) | 31.0 (24.6, 36.3) | 0.759 † | 31.7 (24.4, 36.0) | 30.7 (24.0, 36.1) | 0.625 † | 32.4 (25.2, 37.6) | 31.6 (25.0, 36.5) | 0.601 † |
| Muscle mass (median, IQR) [kg] | 37.4 (34.6, 42.6) | 39.7 (35.7, 48.0) | 0.071 † | 37.4 (34.6, 42.6) | 39.2 (35.0, 47.8) | 0.143 † | 38.2 (34.6, 43.0) | 39.2 (35.2, 48.4) | 0.131 † | 37.8 (34.8, 42.6) | 39.6 (36.1, 47.0) | 0.055 † |
| Percentage of muscle mass (median, IQR) [%] | 64.8 (58.7, 71.5) | 65.1 (59.9, 71.8) | 0.596 † | 65.1 (59.7, 70.8) | 65.0 (60.0, 71.6) | 0.755 † | 64.6 (60.2, 71.4) | 64.9 (60.0, 71.8) | 0.864† | 63.9 (58.8, 70.9) | 64.3 (59.4, 71.1) | 0.696 † |
| Physical fitness tests (passing scores) | ||||||||||||
| Flexibility (n, (%)) | 17 (28.3) | 11 (18.3) | 0.195 ‡ | 32 (53.3) | 24 (40.0) | 0.143 ‡ | 36 (60.0) | 25 (41.7) | 0.045 ‡ | 40 (66.7) | 31 (51.7) | 0.095 ‡ |
| Muscle strength and endurance (n, (%) | 32 (53.3) | 27 (45.0) | 0.361 ‡ | 36 (60.0) | 36 (60.0) | 1.000 ‡ | 29 (48.3) | 29 (48.3) | 1.000 ‡ | 38 (63.3) | 33 (55.0) | 0.353 ‡ |
| Cardiovascular endurance (n, (%)) | 54 (90.0) | 44 (73.3) | 0.018 ‡ | 55 (91.7) | 53 (88.3) | 0.543 ‡ | 42 (70.0) | 42 (70.0) | 1.000 ‡ | 44 (73.3) | 38 (63.3) | 0.239 ‡ |
| Source of Variation | Degrees of Freedom | Sum Square | Mean Square | F | p-Value |
|---|---|---|---|---|---|
| Visit | 3 | 260,754 | 86,918 | 13.246 | <0.001 |
| Group | 1 | 11,653 | 11,653 | 1.776 | 0.183 |
| Visit * Group | 3 | 9471 | 3157 | 0.481 | 0.696 |
| Error | 472 | 3,097,195 | 6562 |
| Group and Visit | Mean Difference | 95% Confidence Interval | p-Value | |
|---|---|---|---|---|
| Lower Bound | Upper Bound | |||
| Intervention group | ||||
| visit 2–visit 1 | 49.2 | 4.1 | 94.2 | 0.021 |
| visit 3–visit 1 | 43.1 | −1.9 | 88.1 | 0.072 |
| visit 4–visit 1 | 72.4 | 27.4 | 117.4 | <0.001 |
| visit 3–visit 2 | −6.1 | −51.1 | 38.9 | 1.000 |
| visit 4–visit 2 | 23.2 | −21.8 | 68.3 | 0.767 |
| visit 4–visit 3 | 29.3 | −15.7 | 74.4 | 0.494 |
| Control group | ||||
| visit 2–visit 1 | 31.9 | −13.1 | 76.9 | 0.379 |
| visit 3–visit 1 | 44.9 | −0.1 | 89.9 | 0.051 |
| visit 4–visit 1 | 56.1 | 11.0 | 101.1 | 0.004 |
| visit 3–visit 2 | 13.0 | −32.0 | 58.0 | 0.988 |
| visit 4–visit 2 | 24.2 | −20.9 | 69.2 | 0.729 |
| visit 4–visit 3 | 11.2 | −33.9 | 56.2 | 0.995 |
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Wattanapisit, A.; Hemarachatanon, P.; Somrak, K.; Manunyanon, S.; Wattanapisit, S.; Khlongdi, P.; Pechpan, K.; Amornsriwatanakul, A.; Katewongsa, P.; Sangkaew, S.; et al. Effectiveness of Physical Activity with Sports Scientist (PASS) Programme Among Patients with Non-Communicable Diseases in Primary Care: A Randomised Controlled Trial. Med. Sci. 2025, 13, 279. https://doi.org/10.3390/medsci13040279
Wattanapisit A, Hemarachatanon P, Somrak K, Manunyanon S, Wattanapisit S, Khlongdi P, Pechpan K, Amornsriwatanakul A, Katewongsa P, Sangkaew S, et al. Effectiveness of Physical Activity with Sports Scientist (PASS) Programme Among Patients with Non-Communicable Diseases in Primary Care: A Randomised Controlled Trial. Medical Sciences. 2025; 13(4):279. https://doi.org/10.3390/medsci13040279
Chicago/Turabian StyleWattanapisit, Apichai, Poramet Hemarachatanon, Kamlai Somrak, Saranrat Manunyanon, Sanhapan Wattanapisit, Phiphat Khlongdi, Kiattisak Pechpan, Areekul Amornsriwatanakul, Piyawat Katewongsa, Sorawat Sangkaew, and et al. 2025. "Effectiveness of Physical Activity with Sports Scientist (PASS) Programme Among Patients with Non-Communicable Diseases in Primary Care: A Randomised Controlled Trial" Medical Sciences 13, no. 4: 279. https://doi.org/10.3390/medsci13040279
APA StyleWattanapisit, A., Hemarachatanon, P., Somrak, K., Manunyanon, S., Wattanapisit, S., Khlongdi, P., Pechpan, K., Amornsriwatanakul, A., Katewongsa, P., Sangkaew, S., Vichitkunakorn, P., Lee, P. Y., Ramdzan, S. N., Salim, H., Ng, C. J., & Stoutenberg, M. (2025). Effectiveness of Physical Activity with Sports Scientist (PASS) Programme Among Patients with Non-Communicable Diseases in Primary Care: A Randomised Controlled Trial. Medical Sciences, 13(4), 279. https://doi.org/10.3390/medsci13040279

