Psoriasis in Patients Attending a Large HIV Clinic in Trinidad
Abstract
:1. Introduction
2. Subjects and Methods
2.1. Inclusion Criteria
- Age 18 years and older
- Patients living with HIV
- Patients attending the MRFTT with a diagnosis of psoriasis
2.2. Exclusion Criteria
- Age under 18 years old
- HIV seronegative individuals
- Patients attending the MRFTT who have not been diagnosed with psoriasis
2.3. Ethical Approval
2.4. Data Collection and Data Analysis
3. Results
4. Discussion
5. Conclusions and Future Recommendations
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
- Griffiths, C.E.M.; Barker, J.N.W.N. Pathogenesis and clinical features of psoriasis. Lancet 2007, 370, 263–271. [Google Scholar] [CrossRef]
- Gelfand, J.M.; Neimann, A.L.; Shin, D.B.; Wang, X.; Margolis, D.J.; Troxel, A.B. Risk of myocardial infarction in patients with psoriasis. JAMA 2006, 296, 1735–1741. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Prodanovich, S.; Kirsner, R.S.; Kravetz, J.D.; Ma, F.; Martinez, L.; Federman, D.G. Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality. Arch. Dermatol. 2009, 145, 700–703. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Qureshi, A.A.; Choi, H.K.; Setty, A.R.; Curhan, G.C. Psoriasis and the risk of diabetes and hypertension: A prospective study of US female nurses. Arch. Dermatol. 2009, 145, 379–382. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Rachakonda, T.D.; Schupp, C.W.; Armstrong, A.W. Psoriasis prevalence among adults in the United States. J. Am. Acad. Dermatol. 2014, 70, 512–516. [Google Scholar] [CrossRef] [PubMed]
- Stern, R.S.; Nijsten, T.; Feldman, S.R.; Margolis, D.J.; Rolstad, T. Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction. J. Investig. Dermatol. Symp. Proc. 2004, 9, 136–139. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- WHO. Global Report of Psoriasis; World Health Organization: Geneva, Switzerland, 2016; Available online: https://apps.who.int/iris/bitstream/handle/10665/204417/9789241565189_eng.pdf?sequence=1&isAllowed=y (accessed on 24 November 2021).
- Boehncke, W.-H.; Schön, M.P. Psoriasis. Lancet 2015, 386, 983–994. [Google Scholar] [CrossRef]
- Spira, R.; Mignard, M.; Doutre, M.S.; Morlat, P.; Dabis, F. Prevalence of Cutaneous Disorders in a Population of HIV-Infected Patients Southwestern France, 1996. Arch. Dermatol. 1998, 134, 1208–1212. [Google Scholar] [CrossRef] [Green Version]
- Menon, K.; Van Voorhees, A.S.; Bebo, B.F.; Gladman, D.D.; Hsu, S.; Kalb, R.E.; Lebwohl, M.G.; Strober, B.E.; National Psoriasis Foundation. Psoriasis in patients with HIV infection: From the medical board of the National Psoriasis Foundation. J. Am. Acad. Dermatol. 2010, 62, 291–299. [Google Scholar] [CrossRef] [PubMed]
- Mallon, E.; Bunker, C.B. HIV-associated psoriasis. AIDS Patient Care STDs 2000, 14, 239–246. [Google Scholar] [CrossRef]
- Alpalhão, M.; Borges-Costa, J.; Filipe, P. Psoriasis in HIV infection: An update. Int. J. STD AIDS 2019, 30, 596–604. [Google Scholar] [CrossRef] [PubMed]
- Muñoz-Pérez, M.A.; Rodriguez-Pichardo, A.; Camacho, F. Dermatological findings correlated with CD4 lymphocyte counts in a prospective 3 year study of 1161 patients with human immunodeficiency virus disease predominantly acquired through intravenous drug abuse. Br. J. Dermatol. 1998, 139, 33–39. [Google Scholar] [CrossRef] [PubMed]
- Morar, N.; Willis-Owen, S.A.; Maurer, T.; Bunker, C.B. HIV-associated psoriasis: Pathogenesis, clinical features, and management. Lancet Infect. Dis. 2010, 10, 470–478. [Google Scholar] [CrossRef]
- Beckford, G. Social and political dimensions of Plantation society. In Persistent Poverty; Oxford University Press: Oxford, UK, 1971; pp. 53–83. [Google Scholar]
- Sheridan, R.B. Africa and the Caribbean in the Atlantic Slave Trade. Am. Hist. Rev. 1972, 77, 15–35. [Google Scholar] [CrossRef]
- Reddock, R. Freedom Denied: Indian Women and Indentureship in Trinidad and Tobago, 1845–1917. Econ. Political Wkly. 1985, 20, WS79–WS87. Available online: http://www.jstor.org/stable/4374974 (accessed on 20 November 2021).
- Bartholomew, C.; Raju, C.C.; Jankey, N. The acquired immune deficiency syndrome in Trinidad. A report on two cases. West Indian Med. J. 1983, 32, 177–180. [Google Scholar]
- Cleghorn, F.R.; Jack, N.; Murphy, J.R.; Edwards, J.; Mahabir, B.; Paul, R.; White, F.; Bartholomew, C.; Blattner, W.A. HIV-1 prevalence and risk factors among sexually transmitted disease clinic attenders in Trinidad. AIDS 1995, 9, 389–394. [Google Scholar] [CrossRef]
- Edwards, R.J.; Cyrus, E.; Bhatt, C.; Lyons, N.; Lavia, L.O.; Boyce, G. Viral suppression among persons living with HIV in Trinidad & Tobago: Implications for targeted prevention programmes. Glob. Public Health 2019, 14, 1569–1577. [Google Scholar] [CrossRef]
- UNAIDS/AIDSinfo. Country Factsheet Trinidad and Tobago 2019; Retrieved from Trinidad and Tobago|UNAIDS; UNAIDS: Geneva, Switzerland, 2019. [Google Scholar]
- Quamina, D.B.E. Spectrum and incidence of skin diseases in Trinidad and Tobago. Carib Med. J. 1975, 36, 23–32. [Google Scholar]
- Suite, M. The epidemiology of psoriasis in a dermatology clinic in a general hospital in Port-of-Spain, Trinidad and Tobago, West Indies. West Indian Med. J. 2006, 55, 399–402. [Google Scholar] [CrossRef]
- La Grenade, L.; Alabi, G.O. Skin disease at the University Hospital of the West Indies [Abstract]. West Indian Med. J. 1980, 29, 222. [Google Scholar]
- Feldman, S.R. A quantitative definition of severe psoriasis for use in clinical trials. J. Dermatol. Treat. 2004, 15, 279. [Google Scholar] [CrossRef] [PubMed]
- Long, C.C.; Finlay, A.Y.; Averill, R.W. The Rule of Hand: 4 hand areas = 2 FTU = 1 g. Arch. Dermatol. 1992, 128, 1130. [Google Scholar] [CrossRef]
- Nevitt, G.J.; Hutchinson, P.E. Psoriasis in the community: Prevalence, severity and patients’ beliefs and attitudes towards the disease. Br. J. Dermatol. 1996, 135, 533–537. [Google Scholar] [CrossRef] [PubMed]
- Henseler, T.; Christophers, E. Psoriasis of early and late onset: Characterization of two types of psoriasis vulgaris. J. Am. Acad. Dermatol. 1985, 13, 450–456. [Google Scholar] [CrossRef]
- Obuch, M.L.; Maurer, T.A.; Becker, B.; Berger, T.G. Psoriasis and human immunodeficiency virus infection. J. Am. Acad. Dermatol. 1992, 27, 667–673. [Google Scholar] [CrossRef]
- Leal, L.; Ribera, M.; Daudén, E. Psoriasis and HIV infection. Actas Dermosifiliogr. 2008, 99, 753–763. [Google Scholar] [CrossRef]
- Gelfand, J.M.; Stern, R.S.; Nijsten, T.; Feldman, S.R.; Thomas, J.; Kist, J.; Rolstad, T.; Margolis, D.J. The prevalence of psoriasis in African Americans: Results from a population-based study. J. Am. Acad. Dermatol. 2005, 52, 23–26. [Google Scholar] [CrossRef]
- Fekete, E. The pattern of diseases of the skin in the Nigerian guinea savanna. Int. J. Dermatol. 1978, 17, 331–338. [Google Scholar] [CrossRef]
- Stingl, P. Hautkrankheiten in Sierra Leone. Hautarzt 1987, 38, 146–154. [Google Scholar]
- Strobel, M.; Ndiaye, B.; Diop, M.; Marchand, J.P. Le psoriasis au Senegal. Dakar Med. 1981, 26, 18–25. [Google Scholar]
- Dogra, S.; Yadav, S. Psoriasis in India: Prevalence and pattern. Indian J. Dermatol. Venereol. Leprol. 2010, 76, 595–601. [Google Scholar] [CrossRef]
- Yeung, H.; Takeshita, J.; Mehta, N.N.; Kimmel, S.E.; Ogdie, A.; Margolis, D.J.; Shin, D.B.; Attor, R.; Troxel, A.B.; Gelfand, J.M. Psoriasis severity and the prevalence of major medical co-morbidities: A population-based study. JAMA Dermatol. 2013, 149, 1173–1179. [Google Scholar] [CrossRef] [Green Version]
- Nakamura, M.; Abrouk, M.; Farahnik, B.; Zhu, T.H.; Bhutani, T. Psoriasis Treatment in HIV-Positive Patients: A Systematic Review of Systemic Immunosuppressive Therapies. Cutis 2018, 101, 38–42. [Google Scholar]
- Queirós, N.; Torres, T. HIV Associated Psoriasis. Actas Dermosifiliogr. 2018, 109, 303–311. [Google Scholar] [CrossRef]
Descriptive Statistic | Total (n = 37) |
---|---|
Mean Age at diagnosis of psoriasis | 37.7 years |
Age Range at diagnosis of psoriasis | 13–70 years |
Age group (years) at diagnosis of psoriasis | |
<19 | 3 (8.1%) |
20–29 | 6 (16.2%) |
30–39 | 14 (37.8%) |
40–49 | 10 (27.0%) |
50–59 | 2 (5.4%) |
60+ | 2 (5.4%) |
Sex | |
Males | 32 (86.5%) |
Females | 5 (13.5) |
Ethnicity | |
African | 21 (56.8%) |
East Indian | 4 (10.8%) |
Mixed | 12 (32.4%) |
Current status | |
Alive | 31 (83.8%) |
Deceased | 6 (16.2%) |
Sexual Orientation | |
Heterosexual | (78.4%) |
Homosexual/Bisexual | 8 (21.6%) |
Severity of psoriasis | |
Mild/moderate | 30 (81.1%) |
Severe/generalised | 7 (18.9%) |
Psoriatic arthritis | |
Yes | 2 (5.4%) |
No | 35 (94.6%) |
Family history of psoriasis | |
Yes | 1 (2.7%) |
No | 36 (97.3%) |
Medication used to treat psoriasis | |
Topical therapy | 35 (94.6%) |
Systemic therapy and Topical therapy | 2 (5.4%) |
Reported improvement with the response to the therapy for psoriasis | |
Yes | 31 (83.8%) |
No | 6 (16.2%) |
Median CD4 count at HIV diagnosis (cells/mm3) | 167 |
Median HIV viral load at HIV diagnosis (copies/mL) | 122,000 |
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Edwards, R.J.; Lavia, L.O.; Edwards, J.; Boyce, G. Psoriasis in Patients Attending a Large HIV Clinic in Trinidad. Med. Sci. 2022, 10, 9. https://doi.org/10.3390/medsci10010009
Edwards RJ, Lavia LO, Edwards J, Boyce G. Psoriasis in Patients Attending a Large HIV Clinic in Trinidad. Medical Sciences. 2022; 10(1):9. https://doi.org/10.3390/medsci10010009
Chicago/Turabian StyleEdwards, Robert Jeffrey, Leon Omari Lavia, Jonathan Edwards, and Gregory Boyce. 2022. "Psoriasis in Patients Attending a Large HIV Clinic in Trinidad" Medical Sciences 10, no. 1: 9. https://doi.org/10.3390/medsci10010009
APA StyleEdwards, R. J., Lavia, L. O., Edwards, J., & Boyce, G. (2022). Psoriasis in Patients Attending a Large HIV Clinic in Trinidad. Medical Sciences, 10(1), 9. https://doi.org/10.3390/medsci10010009