Next Article in Journal
An Open-Circuit Indirect Calorimetry Head Hood System for Measuring Methane Emission and Energy Metabolism in Small Ruminants
Next Article in Special Issue
Characterization of Circular RNAs in Chinese Buffalo (Bubalus bubalis) Adipose Tissue: A Focus on Circular RNAs Involved in Fat Deposition
Previous Article in Journal
Isolation and Culture of Skin-Derived Differentiated and Stem-Like Cells Obtained from the Arabian Camel (Camelus dromedarius)
Previous Article in Special Issue
Genetic Diversity of Indigenous Pigs from South China Area Revealed by SNP Array
Open AccessArticle

Two Insertion/Deletion Variants within SPAG17 Gene Are Associated with Goat Body Measurement Traits

1
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
2
Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin 719000, China
3
Life Science Research Center, Yulin University, Yulin 719000, China
4
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Animals 2019, 9(6), 379; https://doi.org/10.3390/ani9060379
Received: 27 March 2019 / Revised: 8 June 2019 / Accepted: 15 June 2019 / Published: 21 June 2019
(This article belongs to the Collection Applications of Quantitative Genetics in Livestock Production)
Sperm-associated antigen 17 (SPAG17) is a reproduction and skeletal development related gene. This study aimed to identify crucial insertion-deletion (indel) variations, which influence the body measurement traits of goats. Two intronic indels (14 bp and 17 bp indels) were identified by sequencing. In Shaanbei white cashmere goat (SBWC), the different genotypes of the 14 bp indel were markedly associated with goat body height, chest width, body length, and chest depth. The genotypes of the 17 bp indel were significantly associated with body height and chest width. The different combined genotypes were significantly associated with body height and chest width of SBWC and ten traits of Hainan black goat. These results suggested that the 14 and 17 bp indels within SPAG17 can be used in goat growth related traits marker-assisted selection breeding, especially body height.
Sperm-associated antigen 17 (SPAG17) gene encodes a multifunctional cytoplasmic protein, which influences not only reproduction but also skeletal development related body measurement traits, especially body height. Thus, this study aimed to identify crucial insertion-deletion (indel) variations, which influence the body measurement traits of goats in large goat populations (n = 1725). As a result, two intronic indels (14 bp and 17 bp indel) were identified by sequencing. For the two indel loci, the distributions of genotypes and alleles were significantly different between the Shaanbei white cashmere goat (SBWC) and the Hainan black goat (HNBG). In SBWC goats, the different genotypes of the 14 bp indel were markedly associated with goat body height, chest width, body length and chest depth. The genotypes of the 17 bp indel were significantly related to body height and chest width. At the two loci, for all seven analyzed traits of SBWC goat, the growth data of DD homozygotes were the worst, which means that the 14 bp insertion and the 17 bp deletion were beneficial and detrimental variations, respectively. Moreover, the combined genotypes were significantly related to body height and chest width of SBWC goats and ten traits of HNBG. These results suggested that the 14 and 17 bp indels within SPAG17 can be used in goat growth related traits marker-assisted selection breeding, especially body height. View Full-Text
Keywords: goat; SPAG17; insertion-deletion (indel); body measurement traits; body height goat; SPAG17; insertion-deletion (indel); body measurement traits; body height
Show Figures

Figure 1

MDPI and ACS Style

Zhang, S.; Jiang, E.; Wang, K.; Zhang, Y.; Yan, H.; Qu, L.; Chen, H.; Lan, X.; Pan, C. Two Insertion/Deletion Variants within SPAG17 Gene Are Associated with Goat Body Measurement Traits. Animals 2019, 9, 379.

AMA Style

Zhang S, Jiang E, Wang K, Zhang Y, Yan H, Qu L, Chen H, Lan X, Pan C. Two Insertion/Deletion Variants within SPAG17 Gene Are Associated with Goat Body Measurement Traits. Animals. 2019; 9(6):379.

Chicago/Turabian Style

Zhang, Sihuan; Jiang, Enhui; Wang, Ke; Zhang, Yu; Yan, Hailong; Qu, Lei; Chen, Hong; Lan, Xianyong; Pan, Chuanying. 2019. "Two Insertion/Deletion Variants within SPAG17 Gene Are Associated with Goat Body Measurement Traits" Animals 9, no. 6: 379.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop