Next Article in Journal
A Case Report of a Botulism Outbreak in Beef Cattle Due to the Contamination of Wheat by a Roaming Cat Carcass: From the Suspicion to the Management of the Outbreak
Next Article in Special Issue
Estimation of Genetic Parameters by Single-Trait and Multi-Trait Models for Carcass Traits in Hanwoo Cattle
Previous Article in Journal
Concentrations of Aerosol Numbers and Airborne Bacteria, and Temperature and Relative Humidity, and Their Interrelationships in a Tie-Stall Dairy Barn
Previous Article in Special Issue
Four Novel SNPs of MYO1A Gene Associated with Heat-Tolerance in Chinese Cattle
Open AccessArticle

A Comprehensive Analysis of Runs of Homozygosity of Eleven Cattle Breeds Representing Different Production Types

1
University Centre of Veterinary Medicine, University of Agriculture in Kraków, Al. Mickiewicza 24/28, 30-059 Kraków, Poland
2
Department of Animal Molecular Biology, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland
3
Sub-Department of Cattle Breeding and Genetic Resources Conservation, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
4
Department of Animal Reproduction, Anatomy and Genomics, University of Agriculture in Kraków, al. Mickiewicza 24/28, 30-059 Kraków, Poland
*
Author to whom correspondence should be addressed.
Animals 2019, 9(12), 1024; https://doi.org/10.3390/ani9121024
Received: 7 November 2019 / Revised: 15 November 2019 / Accepted: 20 November 2019 / Published: 25 November 2019
(This article belongs to the Collection Applications of Quantitative Genetics in Livestock Production)
Runs of homozygosity (ROH) regions are known to be common in the genomes of cattle and have become a subject of interest of various research in recent years. ROH can be used as a valuable tool to estimate inbreeding, which needs to be controlled in livestock populations. Moreover, analysis of ROH is considered to be an effective method of identifying genome regions that are a subject of selection pressure, which may help in understanding the genetic aspects of production traits under selection. In this study, we analyzed ROH characteristics of 11 cattle breeds, both commercial and native, maintained in Poland. We presented distinct differences in the length, quantity and frequency of ROH between the analyzed breeds as well as in the levels of genomic inbreeding. Higher levels of inbreeding were characteristic for commercial breeds, especially beef breeds. In addition, within ROH islands, we observed a number of genes with a confirmed influence on the level of production traits. The presented results and identified genes can be a basis for further research focused on the identification of genes and markers essential in the determination of the most important production traits in cattle.
In the presented research, BovineSNP50 microarrays (Illumina) were applied to determine runs of homozygosity in the genomes of 11 cattle breeds maintained in Poland. These cattle breeds represent three basic utility types: milk, meat and dual purpose. Analysis of runs of homozygosity allowed the evaluation of the level of autozygosity within each breed in order to calculate the genomic inbreeding coefficient (FROH), as well as to identify regions of the genome with a high frequency of ROH occurrence, which may reflect traces of directional selectin left in their genomes. Visible differences in the length and distribution of runs of homozygosity in the genomes of the analyzed cattle breeds have been observed. The highest mean number and mean sums of lengths of runs of homozygosity were characteristic for Hereford cattle and intermediate for the Holstein-Friesian Black-and-White variety, Holstein-Friesian Red-and-White variety, Simmental, Limousin, Montbeliarde and Charolais breeds. However, lower values were observed for cattle of conserved breeds. Moreover, the selected livestock differed in the level of inbreeding estimated using the FROH coefficient. In regions of the genome with a high frequency of ROH occurrence, which may reflect the impact of directional selection, a number of genes were observed that can be potentially related to the production traits which are under selection pressure for specific production types. The most important detected genes were GHR, MSTN, DGAT1, FABP4, and TRH, with a known influence on the milk and meat traits of the studied cattle breeds. View Full-Text
Keywords: runs of homozygosity; autozygosity; microarray; cattle runs of homozygosity; autozygosity; microarray; cattle
Show Figures

Figure 1

MDPI and ACS Style

Szmatoła, T.; Gurgul, A.; Jasielczuk, I.; Ząbek, T.; Ropka-Molik, K.; Litwińczuk, Z.; Bugno-Poniewierska, M. A Comprehensive Analysis of Runs of Homozygosity of Eleven Cattle Breeds Representing Different Production Types. Animals 2019, 9, 1024. https://doi.org/10.3390/ani9121024

AMA Style

Szmatoła T, Gurgul A, Jasielczuk I, Ząbek T, Ropka-Molik K, Litwińczuk Z, Bugno-Poniewierska M. A Comprehensive Analysis of Runs of Homozygosity of Eleven Cattle Breeds Representing Different Production Types. Animals. 2019; 9(12):1024. https://doi.org/10.3390/ani9121024

Chicago/Turabian Style

Szmatoła, Tomasz; Gurgul, Artur; Jasielczuk, Igor; Ząbek, Tomasz; Ropka-Molik, Katarzyna; Litwińczuk, Zygmunt; Bugno-Poniewierska, Monika. 2019. "A Comprehensive Analysis of Runs of Homozygosity of Eleven Cattle Breeds Representing Different Production Types" Animals 9, no. 12: 1024. https://doi.org/10.3390/ani9121024

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop