Measurements and Visibility of the Pancreatic Ducts on Computed Tomography in 78 Cats Without Clinical Evidence of Pancreatitis
Simple Summary
Abstract
1. Introduction
2. Materials and Methods
- Patients were included if:
- There was contemporaneous standard bloodwork that included normal DGGR lipase, ALT (alanine transferase) or ALKP (alkaline phosphatase).
- There was no clinical evidence of pancreatic disease nor indication in the history of previous pancreatic disease.
- There was no final diagnosis of pancreatic disease identified in the records.
- Patients were excluded if:
- An ultrasound was performed near the time of CT, and pancreatic abnormalities were identified
- fPLi was performed and was abnormal.
- Images were of inadequate quality or did not include the entire pancreas and pancreatic ducts for evaluation.
2.1. The Following Measurements Were Taken
2.1.1. Measurements and Visibility of the Pancreatic Ducts
- Width from outer layer to outer layer, and Likert visibility scale pre and post-contrast, of the right pancreatic duct at its widest point on a dorsal plane reconstruction (Figure 1b).
- Width from outer layer to outer layer, and Likert visibility scale pre and post-contrast, of the common pancreatic duct as it exits the pancreatic parenchyma on a dorsal plane reconstruction (Figure 1c).
- Evaluate each segment for any subjective thickening or irregularity of the walls and for the presence of any mineral attenuation within the duct (subjectively assessed as being distinctly visible on bone window, WL 300, WW 1500).
2.1.2. Measurements of the Duodenal Papilla
- Mean Hounsfield unit (HU) on a circular region of interest (ROI) placed over the duodenal papilla pre- and post-contrast on the transverse image (Figure 2a).
- Likert visibility scale of the duodenal papilla pre- and post-contrast.
- Diameter of the duodenal papilla post-contrast taken perpendicular to the duodenal wall on the transverse image (Figure 1d).
2.1.3. Pancreatic Parenchyma
- The width of the pancreas was measured at 90° to the long axis of the pancreas in the left and right limb at the widest point of the respective limb.
- The mean HU for the same circular ROI, pre- and post-contrast in a section of the pancreas at the level of the pancreatic body (Figure 2b).
- Visibility was recorded using a 5-point Likert scale [29], defined as:
2.2. Statistical Analysis
3. Results
3.1. Measurements Obtained from Imaging
3.1.1. Pancreatic Ducts
3.1.2. Duodenal Papilla Appearance
3.1.3. Pancreatic Parenchyma
3.2. Statistical Analysis
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
HU | Hounsfield unit |
CT | Computed tomography |
ROI | Region of interest |
ALT | Alanine Transaminase |
ALKP | Alkaline phosphatase |
DGGR | (1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester) |
fPLI | Serum feline pancreatic lipase immunoreactivity |
RCVS | Royal college of veterinary surgeons |
Appendix A
Broad Category | Diagnosis | Number |
---|---|---|
Neoplasia | Soft tissue sarcoma, including interscapular | 12 |
Nasal tumour including lymphoma | 10 | |
Pulmonary neoplasia | 7 | |
Mammary tumour | 6 | |
Lymphoma (not nasal) | 4 | |
Thymoma | 3 | |
Osteosarcoma/chondrosarcoma | 2 | |
Iris melanoma | 2 | |
Renal carcinoma | 2 | |
Other—one each of: adrenal tumour, anal sac carcinoma, diffuse carcinoma (thorax), haemangioma, parietal bone mass, retrobulbar, salivary carcinoma, undifferentiated gastric neoplasia, undifferentiated pleural neoplasia | 9 | |
Inflammatory/infectious | Respiratory disease including asthma | 4 |
Pyothorax | 2 | |
Rhinitis (including fungal) | 2 | |
Other—one each of: Aspiration pneumonia, FIP, inflammatory lesion on soft palate, mycobacterial infection from a nasal mass. | 4 | |
Autoimmune | Immune mediated polyarthritis | 1 |
Other | One each of: ARDS, Chylothorax, collapsing trachea, Cruciate disease and non-healing wound, Fractured femur, idiopathic chylothorax, pleuroperitoneal hernia, renal disease | 8 |
Appendix B
Institution | Scanner | Slices | KVP | Tube Current | Slice Thickness |
---|---|---|---|---|---|
A | Toshiba Aquillon | 16 | 100 | 85 | 0.5 mm |
B | GE Revolution Evo | 64 | 120 | 190 | 1.25 |
B | PNMS MX16 | 16 | 120 | 190 | 1 mm |
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Reviewer 1 | Reviewer 2 | Both Combined | |
---|---|---|---|
Measurements | |||
Papilla | 2.4 ± 0.6 (1.3–4.0) | 3.1 ± 0.7 (1.9–5.3) | 2.8 ± 0.7 (1.3–5.3) |
Left duct | 1.3 ± 0.8 (0.6–7.6) | 1.5 ± 0.7 (0.6–4.6) | 1.4 ± 0.8 (0.6–7.6) |
Right duct | 1.2 ± 0.5 (0.5–3.2) | 1.1 ± 0.5 (0.3–2.9) | 1.1 ± 0.5 (0.3–3.2) |
Common duct | 1.7 ± 0.8 (0.7–4.6) | 1.3 ± 0.5 (0.6–3.7) | 1.6 ± 0.8 (0.6–4.6) |
Likert scale | |||
Papilla pre | 1.2 ± 0.4 (1–3) | 1.6 ± 0.8 (1–4) | 1.4 ± 0.7 (1–4) |
Papilla post | 2.5 ± 0.7 (2–5) | 2.9 ± 1.2 (1–5) | 2.7 ± 1.0 (1–5) |
Left pre | 1.7 ± 1.0 (1–5) | 2.0 ± 1.2 (1–5) | 1.9 ± 1.1 (1–5) |
Left post | 3.4 ± 1.0 (2–5) | 3.8 ± 1.3 (1–5) | 3.6 ± 1.1 (1–5) |
Right pre | 1.4 ± 0.8 (1–4) | 1.4 ± 1.0 (1–5) | 1.4 ± 1.0 (1–5) |
Right post | 2.8 ± 0.9 (1–5) | 2.3 ± 1.5 (1–5) | 2.6 ± 1.3 (1–4) |
Common pre | 1.3 ± 0.7 (1–4) | 1.1 ± 0.4 (1–4) | 1.2 ± 0.6 (1–4) |
Common post | 2.9 ± 0.9 (1–5) | 2.5 ± 1.4 (1–5) | 2.7 ± 1.2 (1–5) |
Duct | Reviewer | 1–9 Years | 10+ Years | p-Value |
---|---|---|---|---|
Left | 1 | 1.1 ± 0.4 (0.6–2.3) | 1.4 ± 1.0 (0.6–7.6) | 0.125 |
2 | 1.3 ± 0.6 (0.6–2.8) | 1.6 ± 0.7 (0.6–4.6) | 0.113 | |
Combined | 1.2 ± 0.5 (0.6–2.8) | 1.5 ± 0.9 (0.6–7.6) | - | |
Right | 1 | 1.1 ± 0.4 (0.6–2.6) | 1.2 ± 0.6 (0.5–3.2) | 0.124 |
2 | 1.1 ± 0.5 (0.3–2.0) | 1.1 ± 0.5 (0.3–2.9) | 0.984 | |
Combined | 1.1 ± 0.4 (0.3–2.6) | 1.2 ± 0.5 (0.3–3.2) | - | |
Common | 1 | 1.7 ± 0.8 (0.7–4.0) | 1.7 ± 0.9 (0.7–4.6) | 0.984 |
2 | 1.3 ± 0.7 (0.6–3.7) | 1.3 ± 0.4 (0.7–2.2) | 0.652 | |
Combined | 1.6 ± 0.8 (0.6–4.0) | 1.5 ± 0.7 (0.7–4.6) | - |
Reviewer 1 | Reviewer 2 | R1 vs. R2 | |
---|---|---|---|
ICC | ICC | ICC | |
Measurements | |||
Duodenal papilla diameter | 0.66 | 0.37 | 0.23 |
Left pancreatic duct width | 0.67 | 0.93 | 0.73 |
Right pancreatic duct width | 0.40 | 0.47 | 0.76 |
Common pancreatic duct width | 0.24 | 0.65 | 0.22 |
Likert visibility scales | |||
Duodenal papilla (pre) | −0.13 | 0.40 | 0.06 |
Duodenal papilla (post) | 0.41 | 0.62 | 0.24 |
Left pancreatic duct (pre) | 0.41 | 0.62 | 0.59 |
Left pancreatic duct (post) | 0.85 | 0.88 | 0.66 |
Right pancreatic duct (pre) | 0.43 | 0.68 | 0.59 |
Right pancreatic duct (post) | 0.74 | 0.81 | 0.47 |
Common pancreatic duct (pre) | 0.31 | −0.04 | 0.24 |
Common pancreatic duct (post) | 0.67 | 0.86 | 0.57 |
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Caine, A.; Ma, M.-H.; Herrtage, M.; Sparks, T.; Genain, M.A. Measurements and Visibility of the Pancreatic Ducts on Computed Tomography in 78 Cats Without Clinical Evidence of Pancreatitis. Animals 2025, 15, 2857. https://doi.org/10.3390/ani15192857
Caine A, Ma M-H, Herrtage M, Sparks T, Genain MA. Measurements and Visibility of the Pancreatic Ducts on Computed Tomography in 78 Cats Without Clinical Evidence of Pancreatitis. Animals. 2025; 15(19):2857. https://doi.org/10.3390/ani15192857
Chicago/Turabian StyleCaine, Abby, Man-Hei Ma, Mike Herrtage, Tim Sparks, and Marie Aude Genain. 2025. "Measurements and Visibility of the Pancreatic Ducts on Computed Tomography in 78 Cats Without Clinical Evidence of Pancreatitis" Animals 15, no. 19: 2857. https://doi.org/10.3390/ani15192857
APA StyleCaine, A., Ma, M.-H., Herrtage, M., Sparks, T., & Genain, M. A. (2025). Measurements and Visibility of the Pancreatic Ducts on Computed Tomography in 78 Cats Without Clinical Evidence of Pancreatitis. Animals, 15(19), 2857. https://doi.org/10.3390/ani15192857