Next Article in Journal
Farm Animals Are Long Away from Natural Behavior: Open Questions and Operative Consequences on Animal Welfare
Previous Article in Journal
Pseudo-Placentational Endometrial Hyperplasia in the Bitch: Case Series
Article

The Effect of Xylazine Premedication on the Dose and Quality of Anesthesia Induction with Alfaxalone in Goats

1
College of Veterinary Medicine, Huazhong Agricultural University, No. 1, Shizishan Street, Hongshan District, Wuhan 430070, China
2
Department of Surgery, Radiology and Anaesthesiology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, Egypt
3
National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China
4
Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, Egypt
*
Author to whom correspondence should be addressed.
Academic Editors: Luis Antunes and Robert E. Meyer
Animals 2021, 11(3), 723; https://doi.org/10.3390/ani11030723
Received: 22 January 2021 / Revised: 16 February 2021 / Accepted: 3 March 2021 / Published: 6 March 2021
(This article belongs to the Section Small Ruminants)
Goats have been used as animal models in research and are increasingly kept as companion animals like dogs and cats. Therefore, keeping them to be always healthy and disease free is an important matter for the owners. Anesthesia is a prerequisite for veterinarians to treat animals suffering from medical and surgical disorders. However, information about the efficacy of anesthetic drugs is scant in this species. In this current study, the quality of induction, antinociceptive and cardio-respiratory effects of a newer anesthetic combination “xylazine–alfaxalone” were evaluated. It is well known that the small opening of the oral cavity and long soft palate make intubation in goats a very challenging procedure. The findings demonstrated that xylazine reduced the dose of alfaxalone required for successful intubation and uneventful induction. In addition, this anesthetic regimen produced better antinociception with stability in cardiac function indices, however oxygen supplementation is necessary, especially in compromised animals, to counteract xylazine-associated lowering of hemoglobin oxygen saturation.
Goats have been used as animal models in research and are increasingly kept as companion animals. However, information about effective anesthetic drugs is scarce in this species. The objective of this study was to evaluate the effect of xylazine premedication on alfaxalone induction. Twelve clinically healthy goats weighing 18.5 ± 2 kg were randomly assigned to two groups. Induction was performed with alfaxalone alone intravenously (ALF group) or with xylazine premedication before alfaxalone administration (XYL-ALF group). The quality of induction was scored, induction doses of alfaxalone were determined, and cardiorespiratory parameters and nociceptive thresholds were measured before any treatment(s) (baseline) and at 5, 15, 25 and 35 min after alfaxalone administration. The mean dose of alfaxalone required for induction in the ALF group was greater than that in the XYL-ALF group (p < 0.001). There were no significant changes in diastolic arterial pressure (DAP), mean arterial pressure (MAP) or systolic arterial pressure (SAP) compared to baseline in either group, while hemoglobin oxygen saturation (SpO2) was lower from 5 to 25 min (p < 0.5) in the XYL-ALF group. The nociceptive threshold was significantly higher at 5 min in the XYL-ALF group than in the ALF group (p = 0.0417). Xylazine premedication reduced the required dose of alfaxalone for anesthetic induction and produced better antinociception than alfaxalone alone. In addition, the combination of xylazine and alfaxalone allowed for successful induction; however, oxygen supplementation is necessary to counteract xylazine-associated hypoxemia. View Full-Text
Keywords: alfaxalone; cardiorespiratory parameters; induction; goats; xylazine alfaxalone; cardiorespiratory parameters; induction; goats; xylazine
Show Figures

Figure 1

MDPI and ACS Style

Abouelfetouh, M.M.; Liu, L.; Salah, E.; Sun, R.; Nan, S.; Ding, M.; Ding, Y. The Effect of Xylazine Premedication on the Dose and Quality of Anesthesia Induction with Alfaxalone in Goats. Animals 2021, 11, 723. https://doi.org/10.3390/ani11030723

AMA Style

Abouelfetouh MM, Liu L, Salah E, Sun R, Nan S, Ding M, Ding Y. The Effect of Xylazine Premedication on the Dose and Quality of Anesthesia Induction with Alfaxalone in Goats. Animals. 2021; 11(3):723. https://doi.org/10.3390/ani11030723

Chicago/Turabian Style

Abouelfetouh, Mahmoud M., Lingling Liu, Eman Salah, Rui Sun, Sha Nan, Mingxing Ding, and Yi Ding. 2021. "The Effect of Xylazine Premedication on the Dose and Quality of Anesthesia Induction with Alfaxalone in Goats" Animals 11, no. 3: 723. https://doi.org/10.3390/ani11030723

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop