Epidemiologic, Clinical and Immunological Consequences of Co-Infections during Canine Leishmaniosis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Overview of CanL
3. Immune Responses during CanL
4. Bacterial Co-Infections
4.1. Ehrlichia spp.
4.1.1. Microbe and Epidemiology
4.1.2. Clinical Disease and Biochemical Findings
4.1.3. Immunological Effects
4.2. Anaplasma spp.
4.2.1. Microbe and Epidemiology
4.2.2. Clinical Disease and Hematologic Findings
4.2.3. Immunological Effects
4.3. Borrelia spp.
4.3.1. Microbe and Epidemiology
4.3.2. Clinical Disease
4.3.3. Immunological Effects
5. Protozoal Co-Infections
5.1. Babesia spp.
5.1.1. Microbe and Epidemiology
5.1.2. Clinical Disease and Biochemical Findings
5.1.3. Hematologic and Immunological Effects
5.2. Trypanosoma cruzi
5.2.1. Microbe and Epidemiology
5.2.2. Diagnostic Challenges and Immunologic Effects
5.3. Toxoplasma gondii
5.3.1. Microbe and Epidemiology
5.3.2. Immunological Effects
6. Helminthic Co-Infections
6.1. Helminthes
6.2. Dirofilaria immitis
6.2.1. Epidemiology and Clinical Disease
6.2.2. Immunological Effects
7. Fungal Co-Infection
7.1. Paracoccidioides brasiliensis
7.1.1. Epidemiology and Clinical Disease
7.1.2. Immunological Effects
8. Effects on Diagnosis and Consideration of Cross-Reactions
9. Treatment Implications and Complexities
10. Prevention Strategies
11. Concluding Remarks
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pathogen | Type of Pathogen | Main Vector(s) | Region(s) Primarily Found | Reference(s) |
---|---|---|---|---|
Leishmania infantum | Protozoa | Phlebotomus spp. | Mediterranean basin Southern Europe Northern Africa | [1,2] |
Lutzomyia longipalpis | South America | [2,3] | ||
None | North America (enzootic) | [6,7] | ||
Ehrlichia canis | Bacteria | Rhipicephalus sanguineus | North America South America Mediterranean basin | [13,14,15,16] |
Ehrlichia ewingii | Bacteria | Amblyomma americanum | North America | [13,14,15,17] |
Ehrlichia chaffeensis | Bacteria | Amblyomma americanum | North America | [13,14,15] |
Anaplasma phagocytophilum | Bacteria | Ixodes scapularis | North America | [18] |
Ixodes pacificus | Western U.S. | [18] | ||
Ixodes ricinus | Europe | [18,19] | ||
Anaplasma platys | Bacteria | Rhipicephalus sanguineus | Brazil Europe | [9,16,20] |
Borrelia burgdorferi | Bacteria | Ixodes scapularis | North America | [21,22,23] |
Ixodes pacificus | Western U.S. | [21] | ||
Borrelia garinii | Bacteria | Ixodes ricinus | Europe | [19,22,24] |
Borrelia afzelii | Bacteria | Ixodes ricinus | Europe | [22,24] |
Babesia canis | Protozoa | Dermacentor reticulatus | Europe | [25,26,27] |
Rhipicephalus sanguineus | Brazil | [25,28] | ||
Babesia vogeli | Protozoa | Rhipicephalus sanguineus | Brazil | [28] |
Babesia gibsoni | Protozoa | Haemaphysalis bispinosa | Asia | [29] |
Haemaphysalis longicornis | Asia | [27] | ||
Trypanosoma cruzi | Protozoa | Triatoma gerstaeckeri, T. sanguisuga | North America | [30,31,32,33,34,35,36] |
T. dimidiata | Central America | [33,37] | ||
T. infestans | South America | [33,38,39] | ||
Toxoplasma gondii | Protozoa | None | South America North America Europe Asia | [40,41] |
Dirofilaria immitis | Helminth | Aedes, Anopheles, Culex | North America, South America, Europe | [42,43,44,45,46,47] |
Paracoccidiodes brasiliensis | Fungi | None | South America Central America | [48] |
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Beasley, E.A.; Pessôa-Pereira, D.; Scorza, B.M.; Petersen, C.A. Epidemiologic, Clinical and Immunological Consequences of Co-Infections during Canine Leishmaniosis. Animals 2021, 11, 3206. https://doi.org/10.3390/ani11113206
Beasley EA, Pessôa-Pereira D, Scorza BM, Petersen CA. Epidemiologic, Clinical and Immunological Consequences of Co-Infections during Canine Leishmaniosis. Animals. 2021; 11(11):3206. https://doi.org/10.3390/ani11113206
Chicago/Turabian StyleBeasley, Erin A., Danielle Pessôa-Pereira, Breanna M. Scorza, and Christine A. Petersen. 2021. "Epidemiologic, Clinical and Immunological Consequences of Co-Infections during Canine Leishmaniosis" Animals 11, no. 11: 3206. https://doi.org/10.3390/ani11113206