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Article

A Nutritional Supplement (DìLshTM) Improves the Inflammatory Cytokines Response, Oxidative Stress Markers and Clinical Signs in Dogs Naturally Infected by Leishmania infantum

1
Department of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Napoli, Italy
2
Department of Health Sciences, University Magna Graecia, Catanzaro, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Animals 2020, 10(6), 938; https://doi.org/10.3390/ani10060938
Received: 6 May 2020 / Revised: 22 May 2020 / Accepted: 27 May 2020 / Published: 29 May 2020
(This article belongs to the Collection Nutraceuticals and Animal Physiology: Performance and Welfare)
The effects of a commercial nutraceutical supplementation in dogs naturally infected by Leishmania infantum were evaluated. Such a nutraceutical supplement was proposed to be added to the dog diet in order to improve the physiological immune response during chronic leishmaniosis. The present study suggests that such a supplement possesses anti-inflammatory and antioxidant properties that can lead to a clinical improvement in dogs naturally infected by Leishmania infantum.
The possibility to associate nutraceuticals, as immune-modulating tools, to the treatment of visceral leishmaniosis is a matter of great interest. In this study, we investigated whether the administration of a nutritional supplement (DìLshTM, Dynamopet SRL, Verona, Italy) was able to exert beneficial effects on the inflammatory state and oxidative stress of the dogs naturally infected by Leishmania infantum. To this purpose, specific parameters, namely Tumor Necrosis Factor -alpha (TNFα), Interleukin-6 (IL-6), Inteleukin-10 (IL-10), leptin, derivates of Reactive Oxigen Metabolites (d-Roms) and Biological Antioxidant Potential (BAP), as well as the haematological and biochemical profiles of the infected dogs, were investigated upon the treatment with the nutritional supplement and compared with the conventional pharmacological anti-Leishmania therapy. The animals underwent complete clinical examination and blood sample collection before (T0) and 3 months after (T90) the onset of the two treatments. The two treatments showed similar results: significant clinical improvement, ELISA positivity and IgG decrease, an increase in IL-10, and a decrease in IL-6 were observed in animals treated with the nutritional supplement. A decrease in d-Roms and an increase in BAP were also detected in both groups. On the whole, the nutritional supplement possesses anti-inflammatory and antioxidant properties, suggesting that it may support animals’ health and be useful to extend the time a drug therapy is needed. View Full-Text
Keywords: leishmaniosis; dogs; nutraceuticals; oxidative stress; cytokines; leptin leishmaniosis; dogs; nutraceuticals; oxidative stress; cytokines; leptin
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MDPI and ACS Style

Mastellone, V.; Musco, N.; Vassalotti, G.; Piantedosi, D.; Vastolo, A.; Cutrignelli, M.I.; Britti, D.; Cortese, L.; Lombardi, P. A Nutritional Supplement (DìLshTM) Improves the Inflammatory Cytokines Response, Oxidative Stress Markers and Clinical Signs in Dogs Naturally Infected by Leishmania infantum. Animals 2020, 10, 938. https://doi.org/10.3390/ani10060938

AMA Style

Mastellone V, Musco N, Vassalotti G, Piantedosi D, Vastolo A, Cutrignelli MI, Britti D, Cortese L, Lombardi P. A Nutritional Supplement (DìLshTM) Improves the Inflammatory Cytokines Response, Oxidative Stress Markers and Clinical Signs in Dogs Naturally Infected by Leishmania infantum. Animals. 2020; 10(6):938. https://doi.org/10.3390/ani10060938

Chicago/Turabian Style

Mastellone, Vincenzo, Nadia Musco, Giuseppe Vassalotti, Diego Piantedosi, Alessandro Vastolo, Monica Isabella Cutrignelli, Domenico Britti, Laura Cortese, and Pietro Lombardi. 2020. "A Nutritional Supplement (DìLshTM) Improves the Inflammatory Cytokines Response, Oxidative Stress Markers and Clinical Signs in Dogs Naturally Infected by Leishmania infantum" Animals 10, no. 6: 938. https://doi.org/10.3390/ani10060938

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