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Open AccessCase Report

The First Application of Nanoelectrochemotherapy in Feline Oral Malignant Melanoma Treatment—Case Study

1
Department of Surgery, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
2
Department of Molecular and Cellular Biology, Wroclaw Medical University, 50-556 Wroclaw, Poland
3
Institute of High Magnetic Fields, Vilnius Gediminas Technical University, 03227 Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Animals 2020, 10(4), 556; https://doi.org/10.3390/ani10040556
Received: 4 March 2020 / Revised: 23 March 2020 / Accepted: 24 March 2020 / Published: 26 March 2020
(This article belongs to the Special Issue Spontaneous Neoplasms in Animals)
The current study concerns feline melanoma of the oral cavity, which is rather rarely diagnosed but is usually correlated with poor prognosis. Here we proposed a new treatment modality using CO2 laser surgery with pulsed electric fields with ultra-short pulses in combination with bleomycin. The applied nanoelectrochemotherapy resulted in positive response and satisfactory animal recovery. Thus, nanosecond electroporation seems a reasonable anticancer approach in domestic animals.
Background: The aim of this study was to present the first domestic animal trial of nanosecond electroporation with chemotherapy and CO2 laser surgery. Methods: sixteen-year-old domestic cat with diagnosed melanoma on oral cavity was the case used in the study. Firstly, CO2 laser surgery was used for the removal of most of tumor mass. Then nanoelectrochemotherapy with bleomycin was applied including appropriate margin of healthy tissue. A 15 ± 4 kV/cm × 15 ns pulsing protocol was employed with a total of 800 ± 100 pulses. Only one session of nanoelectrochemotherapy (nanoECT) was performed. Results and conclusions: during the next two weeks areas of focal necrosis were replaced by the granulation tissue. Complete wound healing was observed four weeks after initial treatment. After 15 weeks post treatment, no local recurrence was apparent. View Full-Text
Keywords: feline melanoma; electrochemotherapy; nanosecond pulsed electric field; CO2 laser feline melanoma; electrochemotherapy; nanosecond pulsed electric field; CO2 laser
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MDPI and ACS Style

Tunikowska, J.; Antończyk, A.; Rembiałkowska, N.; Jóźwiak, Ł.; Novickij, V.; Kulbacka, J. The First Application of Nanoelectrochemotherapy in Feline Oral Malignant Melanoma Treatment—Case Study. Animals 2020, 10, 556.

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