Mammary Transcriptome Profile during Peak and Late Lactation Reveals Differentially Expression Genes Related to Inflammation and Immunity in Chinese Holstein
College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China
Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
Jiangsu Co-innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou 225009, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 2 February 2020 / Revised: 17 March 2020 / Accepted: 18 March 2020 / Published: 19 March 2020
(This article belongs to the Section Cattle
Milk somatic cell count, referring to the total number of somatic cells per milliliter of bovine milk, changes regularly during the lactation cycle. The somatic cell count of healthy cows is usually higher in late lactation than in peak lactation. When the inflammatory response in dairy cow mammary gland becomes more intense, the milk somatic cell count increases together with the reduction of milk quality and yield. Autoimmunity was thought to play an important role in the prevention of mastitis in late lactation of dairy cattle. However, the underlying mechanisms related to the gene expression levels during the process remain unknown. In this study, transcriptome sequencing was performed to screen the differentially expressed genes related to the inflammation and immunity in healthy Chinese Holstein mammary glands. Our findings are helpful to understand the physiological functions of mammary inflammation of Chinese Holstein during late lactation.