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Porcine Digestible Peptides (PDP) in Weanling Diets Regulates the Expression of Genes Involved in Gut Barrier Function, Immune Response and Nutrient Transport in Nursery Pigs

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Department of Animal and Food Sciences, Animal Nutrition and Welfare Service, Autonomous University of Barcelona, 08193 Bellaterra, Spain
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Plant and Animal Genomics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, 08193 Bellaterra, Spain
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Department of Animal Production, Agrarian University of Ecuador, Guayaquil 090108, Ecuador
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Department of Mathematics, Area of Statistics and Operations Research, Autonomous University of Barcelona, 08193 Bellaterra, Spain
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R&D Animal Nutrition Department, Bioiberica S.A.U., 08389 Palafolls, Spain
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Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain
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Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain
*
Author to whom correspondence should be addressed.
Animals 2020, 10(12), 2368; https://doi.org/10.3390/ani10122368
Received: 20 October 2020 / Revised: 5 December 2020 / Accepted: 8 December 2020 / Published: 10 December 2020
(This article belongs to the Section Animal Nutrition)
Porcine digestive peptides (PDP) are a coproduct of the heparin industry obtained from the enzymatic hydrolysis of porcine intestinal mucosa. They have proven to be a valid substitute for other high quality dietary protein sources for piglets, like spray-dried plasma (SDP), but knowledge about their influence on intestinal function is still scarce. This study found that substituting soybean ingredients with PDP and SDP to the diets of weaned piglets increased growth rate at 14 d post-weaning. In addition, the combination of PDP with SDP increased the expression of certain genes related to intestinal function in the jejunum, which suggests that this combination might have functional properties that contribute to improving the intestinal health of the pigs, although more research is needed to confirm it.
This study was conducted to investigate the effects of dietary supplementation of porcine digestible peptides (PDP), spray-dried plasma (SDP), or a combination of both, on growth performance and the expression of genes related to intestinal function of weaned pigs. A total of 180 piglets (trial 1) and 198 piglets (trial 2) were used to evaluate the partial substitution of soybean ingredients with 2% SDP or 2% PDP (trial 1), and with 3% SDP or the combination of 1% SDP and 2% PDP (SDP-PDP; trial 2) during the pre-starter period (0–14 days). The gene expression of 56 genes was quantified in a qPCR platform in jejunum and ileum samples obtained from piglets 14 d after weaning (trial 2). Piglets fed SDP, PDP and SDP-PDP had a higher body weight (BW), average daily gain (ADG) and feed efficiency (G:F) than the soybean control on day 14 (p < 0.05). In addition, the combination of SDP and PDP upregulated ten genes in jejunum samples (p < 0.05) related to intestinal function. More research is needed to confirm that gene expression upregulation by PDP in combination with SDP has an impact on intestinal function and to elucidate its underlying mechanisms. View Full-Text
Keywords: gene expression; high throughput RT-qPCR; intestinal function; piglet; porcine digestible peptides gene expression; high throughput RT-qPCR; intestinal function; piglet; porcine digestible peptides
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MDPI and ACS Style

González-Solé, F.; Criado-Mesas, L.; Villodre, C.; García, W.C.; Farré, M.; Borda, E.; Pérez-Cano, F.J.; Folch, J.M.; Solà-Oriol, D.; Pérez, J.F. Porcine Digestible Peptides (PDP) in Weanling Diets Regulates the Expression of Genes Involved in Gut Barrier Function, Immune Response and Nutrient Transport in Nursery Pigs. Animals 2020, 10, 2368. https://doi.org/10.3390/ani10122368

AMA Style

González-Solé F, Criado-Mesas L, Villodre C, García WC, Farré M, Borda E, Pérez-Cano FJ, Folch JM, Solà-Oriol D, Pérez JF. Porcine Digestible Peptides (PDP) in Weanling Diets Regulates the Expression of Genes Involved in Gut Barrier Function, Immune Response and Nutrient Transport in Nursery Pigs. Animals. 2020; 10(12):2368. https://doi.org/10.3390/ani10122368

Chicago/Turabian Style

González-Solé, Francesc, Lourdes Criado-Mesas, Carmen Villodre, Wellington C. García, Mercè Farré, Elisabet Borda, Francisco J. Pérez-Cano, Josep M. Folch, David Solà-Oriol, and José F. Pérez 2020. "Porcine Digestible Peptides (PDP) in Weanling Diets Regulates the Expression of Genes Involved in Gut Barrier Function, Immune Response and Nutrient Transport in Nursery Pigs" Animals 10, no. 12: 2368. https://doi.org/10.3390/ani10122368

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