Stress-Induced Phosphaturia in Weaned Piglets
Department of Bioinformatics, Institute of Biochemistry and Biophysics PAS, ul. Pawinskiego 5A, 02-106 Warsaw, Poland
Department of Large Animals with Clinic, Warsaw University of Life Sciences, Nowoursynowska 100, 02-797 Warsaw, Poland
Authors to whom correspondence should be addressed.
These authors equally contributed to the study.
Received: 13 October 2020 / Revised: 18 November 2020 / Accepted: 21 November 2020 / Published: 26 November 2020
The weaning period is a critical period in piglets’ lives. Multiple elements, including diet change, social stress, handling, and change of physical environment, contribute to enormous stress that has health implications. This period has been studied extensively in the past, but some gaps in our knowledge remain. We attempted to fill them by biochemical characterizations of the changes in blood and urine before and after the weaning. The major finding is the observation of the release of phosphate in the urine in the apparent absence of a factor other than weaning. This release is followed by the drop of the phosphate in the blood. Additionally, we observed a population-level Bohr effect, suggesting a decrease in oxygen levels in the tissues. These results point to the development of systemic hypophosphatemia, even though modern diets used in pig breeding have an excess of phosphorus typically. This study sheds new light on the weaning period and will help researchers and veterinary practices in improving design studies and treatments around that time.