Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections
Abstract
:1. Introduction
2. Biofilm Formation in the Gastrointestinal Tract: The Blurry Line between Health and Disease
3. Gut Biofilm Communities: Location, Organization, and Composition
4. Health and Disease: Non-Invasive versus Invasive Gut Microbial Biofilms
5. Diversity of Interactions and Phenotypes in the Gut Biofilm Communities
5.1. Competitive and Cooperative Behaviors in a Biofilm
5.2. Phenotypic and Metabolic Heterogeneity Inside a Biofilm
6. Diverse Gut and Microbiota-Derived Signals Induce Biofilm Formation in Commensal Bacteria and Enteropathogens
6.1. Host-Derived Factors and Biofilm Formation
6.2. Antibiotics Affecting Biofilm Formation
6.3. Microbiota Metabolites and Biofilm Formation
6.4. Bacterial and Phages Interactions Affect Biofilm Formation
7. The Case for C. difficile
8. Biofilm Formation in C. difficile
8.1. In Vitro Models, Quantification, and Visualization
8.2. In Vivo Models and Clinical Data
8.3. Composition of the In Vitro Biofilm Matrix
8.4. How Is eDNA Released into the Biofilm Matrix?
8.5. Surface Structures and Their Importance in Biofilm Formation
9. Regulation of Biofilm Formation
9.1. Are SinR and SinR’ Involved?
9.2. Is Quorum Sensing Important for Biofilm Formation?
9.3. The Important Role of c-di-GMP in C. difficile Biofilm Formation
9.4. Post-Transcriptional Regulation and Phenotypic Heterogeneity in Biofilms
10. What Induces Biofilm Formation?
10.1. Induction of Biofilm Formation by Antibiotics
10.2. Induction of Biofilm Formation by DOC
11. The Importance of Metabolism in Biofilm Formation
12. Role of the Microbiota-C. difficile Interactions in Biofilm Formation
13. Gut Biofilm: A Shelter against Stresses for C. difficile
14. Persistence in the Gut: Spores, Biofilms, or Both?
15. Refining the Infectious Cycle of C. difficile: Metabolic Landscape as a Determinant of Biofilm Formation, Pathogenesis or Sporulation
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Meza-Torres, J.; Auria, E.; Dupuy, B.; Tremblay, Y.D.N. Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections. Microorganisms 2021, 9, 1922. https://doi.org/10.3390/microorganisms9091922
Meza-Torres J, Auria E, Dupuy B, Tremblay YDN. Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections. Microorganisms. 2021; 9(9):1922. https://doi.org/10.3390/microorganisms9091922
Chicago/Turabian StyleMeza-Torres, Jazmin, Emile Auria, Bruno Dupuy, and Yannick D. N. Tremblay. 2021. "Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections" Microorganisms 9, no. 9: 1922. https://doi.org/10.3390/microorganisms9091922