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Article

Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal

1
Service de Parasitologie—Mycologie, Faculté de Médecine, Pharmacie et Odontologie, Université Cheikh Anta Diop, Dakar BP 5005, Senegal
2
Centre for Emerging, Endemic and Exotic Diseases, Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Herts AL9 7TA, UK
3
London Centre for Neglected Tropical Disease Research (LCNTDR), Faculty of Medicine (St Mary’s Hospital Campus), Imperial College, London W2 1PG, UK
4
Réseau International Schistosomoses, Environnement, Aménagement et Lutte (RISEAL-Niger), Niamey BP 13724, Niger
5
Institut Supérieur de Formation Agricole et Rurale, Université de Thiès, Bambey BP 54, Senegal
6
Unité de Formation et de Recherche des Sciences Agronomiques, d’Aquaculture et de Technologies Alimentaires, Université Gaston Berger, Saint-Louis BP 234, Senegal
*
Authors to whom correspondence should be addressed.
These first authors contributed equally to this manuscript.
Current address: Big Data Institute, University of Oxford, Oxford OX3 7LF, UK.
Academic Editor: Jérôme Boissier
Microorganisms 2021, 9(8), 1776; https://doi.org/10.3390/microorganisms9081776
Received: 24 June 2021 / Revised: 3 August 2021 / Accepted: 17 August 2021 / Published: 20 August 2021
(This article belongs to the Special Issue Schistosoma and Schistosomiasis)
Hybridization of infectious agents is a major emerging public and veterinary health concern at the interface of evolution, epidemiology, and control. Whilst evidence of the extent of hybridization amongst parasites is increasing, their impact on morbidity remains largely unknown. This may be predicted to be particularly pertinent where parasites of animals with contrasting pathogenicity viably hybridize with human parasites. Recent research has revealed that viable zoonotic hybrids between human urogenital Schistosoma haematobium with intestinal Schistosoma species of livestock, notably Schistosoma bovis, can be highly prevalent across Africa and beyond. Examining human populations in Senegal, we found increased hepatic but decreased urogenital morbidity, and reduced improvement following treatment with praziquantel, in those infected with zoonotic hybrids compared to non-hybrids. Our results have implications for effective monitoring and evaluation of control programmes, and demonstrate for the first time the potential impact of parasite hybridizations on host morbidity. View Full-Text
Keywords: hybridization; schistosomiasis; morbidity; ultrasonography; disease control; one health hybridization; schistosomiasis; morbidity; ultrasonography; disease control; one health
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MDPI and ACS Style

Fall, C.B.; Lambert, S.; Léger, E.; Yasenev, L.; Garba, A.D.; Diop, S.D.; Borlase, A.; Catalano, S.; Faye, B.; Walker, M.; Sene, M.; Webster, J.P. Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal. Microorganisms 2021, 9, 1776. https://doi.org/10.3390/microorganisms9081776

AMA Style

Fall CB, Lambert S, Léger E, Yasenev L, Garba AD, Diop SD, Borlase A, Catalano S, Faye B, Walker M, Sene M, Webster JP. Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal. Microorganisms. 2021; 9(8):1776. https://doi.org/10.3390/microorganisms9081776

Chicago/Turabian Style

Fall, Cheikh B., Sébastien Lambert, Elsa Léger, Lucy Yasenev, Amadou D. Garba, Samba D. Diop, Anna Borlase, Stefano Catalano, Babacar Faye, Martin Walker, Mariama Sene, and Joanne P. Webster 2021. "Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal" Microorganisms 9, no. 8: 1776. https://doi.org/10.3390/microorganisms9081776

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