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Article

Characterizing the Cattle Gut Microbiome in Farms with a High and Low Prevalence of Shiga Toxin Producing Escherichia coli

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Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
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Department of Large Animal Clinical Sciences, College Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
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Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA
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Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48824, USA
*
Author to whom correspondence should be addressed.
Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA.
Zoetis Inc., Kalamazoo, MI 49007, USA.
§
College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Academic Editor: Jorge Blanco
Microorganisms 2021, 9(8), 1737; https://doi.org/10.3390/microorganisms9081737
Received: 18 June 2021 / Revised: 6 August 2021 / Accepted: 12 August 2021 / Published: 14 August 2021
(This article belongs to the Special Issue Gut Microbiome of Farm Animals in Health and Disease)
Cattle are the main reservoirs of Shiga toxin producing Escherichia coli (STEC), a major foodborne pathogen associated with acute enteric disease and hemolytic–uremic syndrome in humans. A total of 397 beef and dairy cattle from 5 farms were included in this study, of which 660 samples were collected for 16S rRNA gene sequencing. The microbiota of farms with a high-STEC prevalence (HSP) had greater richness compared to those of farms with a low-STEC prevalence (LSP). Longitudinal analyses showed STEC-shedders from LSP farms had higher microbiome diversity; meanwhile, changes in the microbiome composition in HSP farms were independent of the STEC shedding status. Most of the bacterial genera associated with STEC shedding in dairy farms were also correlated with differences in the percentage of forage in diet and risk factors of STEC carriage such as days in milk, number of lactations, and warm temperatures. Identifying factors that alter the gut microbiota and enable STEC colonization in livestock could lead to novel strategies to prevent fecal shedding and the subsequent transmission to humans. View Full-Text
Keywords: microbiota; cattle; Shiga toxin producing Escherichia coli; bacterial shedding microbiota; cattle; Shiga toxin producing Escherichia coli; bacterial shedding
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MDPI and ACS Style

Vasco, K.; Nohomovich, B.; Singh, P.; Venegas-Vargas, C.; Mosci, R.E.; Rust, S.; Bartlett, P.; Norby, B.; Grooms, D.; Zhang, L.; Manning, S.D. Characterizing the Cattle Gut Microbiome in Farms with a High and Low Prevalence of Shiga Toxin Producing Escherichia coli. Microorganisms 2021, 9, 1737. https://doi.org/10.3390/microorganisms9081737

AMA Style

Vasco K, Nohomovich B, Singh P, Venegas-Vargas C, Mosci RE, Rust S, Bartlett P, Norby B, Grooms D, Zhang L, Manning SD. Characterizing the Cattle Gut Microbiome in Farms with a High and Low Prevalence of Shiga Toxin Producing Escherichia coli. Microorganisms. 2021; 9(8):1737. https://doi.org/10.3390/microorganisms9081737

Chicago/Turabian Style

Vasco, Karla, Brian Nohomovich, Pallavi Singh, Cristina Venegas-Vargas, Rebekah E. Mosci, Steven Rust, Paul Bartlett, Bo Norby, Daniel Grooms, Lixin Zhang, and Shannon D. Manning 2021. "Characterizing the Cattle Gut Microbiome in Farms with a High and Low Prevalence of Shiga Toxin Producing Escherichia coli" Microorganisms 9, no. 8: 1737. https://doi.org/10.3390/microorganisms9081737

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