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Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017

1
Department of General Paediatrics, Medical University of Graz, 8036 Graz, Austria
2
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria
3
Department of Neurology, Medical University of Graz, 8036 Graz, Austria
4
Department of Infectious Diseases and Febrile Conditions, University Clinical Center Maribor, 2000 Maribor, Slovenia
5
Biology Centre of the Czech Academy of Sciences, Institute of Parasitology, Ceske Budejovice, 370 01 Ceske Budejovice, Czech Republic
6
Veterinary Research Institute, 621 00 Brno, Czech Republic
7
Deptartment of Infectious Diseases, University Hospital Brno, 625 00 Brno, Czech Republic
8
Department of Infectious Diseases, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic
9
Department of Children’s Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, 613 00 Brno, Czech Republic
10
Department of Infectious Diseases, Hospital Ceske Budejovice, 370 01 Ceske Budejovice, Czech Republic
11
Department of Infectious Disease and Travel Medicine, University Hospital Plzeň and Faculty of Medicine in Pilsen, Charles University, 306 05 Plzeň, Czech Republic
12
Department of Paediatrics, Children Clinical University Hospital, Riga Stradins University, LV-1004 Riga, Latvia
13
Department of Neurology and Neurosurgery, Riga East University Hospital, Riga Stradins University, LV-1004 Riga, Latvia
14
Department of Infectious Diseases, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
15
Department of Infectious Diseases and Neuroinfections, Medical University Bialystok, 15-089 Bialystok, Poland
16
Department of Infectious Diseases, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Members of the EU-TICKBO STUDY GROUP is provided in the Acknowledgments.
Academic Editor: Pat Nuttall
Microorganisms 2021, 9(7), 1420; https://doi.org/10.3390/microorganisms9071420
Received: 10 June 2021 / Revised: 25 June 2021 / Accepted: 28 June 2021 / Published: 30 June 2021
(This article belongs to the Special Issue Tick-Borne Encephalitis)
Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease. View Full-Text
Keywords: tick-borne encephalitis; vaccine-preventable disease; meningomyelitis; central paresis; peripheral paresis tick-borne encephalitis; vaccine-preventable disease; meningomyelitis; central paresis; peripheral paresis
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MDPI and ACS Style

Kohlmaier, B.; Schweintzger, N.A.; Sagmeister, M.G.; Švendová, V.; Kohlfürst, D.S.; Sonnleitner, A.; Leitner, M.; Berghold, A.; Schmiedberger, E.; Fazekas, F.; Pichler, A.; Rejc-Marko, J.; Růžek, D.; Dufková, L.; Čejková, D.; Husa, P.; Pýchová, M.; Krbková, L.; Chmelík, V.; Štruncová, V.; Zavadska, D.; Karelis, G.; Mickiene, A.; Zajkowska, J.; Bogovič, P.; Strle, F.; Zenz, W.; the EU-TICK-BO STUDY GROUP. Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017. Microorganisms 2021, 9, 1420. https://doi.org/10.3390/microorganisms9071420

AMA Style

Kohlmaier B, Schweintzger NA, Sagmeister MG, Švendová V, Kohlfürst DS, Sonnleitner A, Leitner M, Berghold A, Schmiedberger E, Fazekas F, Pichler A, Rejc-Marko J, Růžek D, Dufková L, Čejková D, Husa P, Pýchová M, Krbková L, Chmelík V, Štruncová V, Zavadska D, Karelis G, Mickiene A, Zajkowska J, Bogovič P, Strle F, Zenz W, the EU-TICK-BO STUDY GROUP. Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017. Microorganisms. 2021; 9(7):1420. https://doi.org/10.3390/microorganisms9071420

Chicago/Turabian Style

Kohlmaier, Benno, Nina A. Schweintzger, Manfred G. Sagmeister, Vendula Švendová, Daniela S. Kohlfürst, Astrid Sonnleitner, Manuel Leitner, Andrea Berghold, Erich Schmiedberger, Franz Fazekas, Alexander Pichler, Jana Rejc-Marko, Daniel Růžek, Lucie Dufková, Darina Čejková, Petr Husa, Martina Pýchová, Lenka Krbková, Václav Chmelík, Věra Štruncová, Dace Zavadska, Guntis Karelis, Aukse Mickiene, Joanna Zajkowska, Petra Bogovič, Franc Strle, Werner Zenz, and the EU-TICK-BO STUDY GROUP. 2021. "Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017" Microorganisms 9, no. 7: 1420. https://doi.org/10.3390/microorganisms9071420

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