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Viruses Like Sugars: How to Assess Glycan Involvement in Viral Attachment

Institute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland
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Author to whom correspondence should be addressed.
Academic Editor: Stefano Aquaro
Microorganisms 2021, 9(6), 1238; https://doi.org/10.3390/microorganisms9061238
Received: 25 May 2021 / Revised: 1 June 2021 / Accepted: 4 June 2021 / Published: 7 June 2021
(This article belongs to the Special Issue Antiviral Research)
The first step of viral infection requires interaction with the host cell. Before finding the specific receptor that triggers entry, the majority of viruses interact with the glycocalyx. Identifying the carbohydrates that are specifically recognized by different viruses is important both for assessing the cellular tropism and for identifying new antiviral targets. Advances in the tools available for studying glycan–protein interactions have made it possible to identify them more rapidly; however, it is important to recognize the limitations of these methods in order to draw relevant conclusions. Here, we review different techniques: genetic screening, glycan arrays, enzymatic and pharmacological approaches, and surface plasmon resonance. We then detail the glycan interactions of enterovirus D68 and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlighting the aspects that need further clarification. View Full-Text
Keywords: attachment receptor; viruses; glycan; sialic acid; heparan sulfate; HBGA; SARS-CoV-2; EV-D68 attachment receptor; viruses; glycan; sialic acid; heparan sulfate; HBGA; SARS-CoV-2; EV-D68
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MDPI and ACS Style

Mathez, G.; Cagno, V. Viruses Like Sugars: How to Assess Glycan Involvement in Viral Attachment. Microorganisms 2021, 9, 1238. https://doi.org/10.3390/microorganisms9061238

AMA Style

Mathez G, Cagno V. Viruses Like Sugars: How to Assess Glycan Involvement in Viral Attachment. Microorganisms. 2021; 9(6):1238. https://doi.org/10.3390/microorganisms9061238

Chicago/Turabian Style

Mathez, Gregory, and Valeria Cagno. 2021. "Viruses Like Sugars: How to Assess Glycan Involvement in Viral Attachment" Microorganisms 9, no. 6: 1238. https://doi.org/10.3390/microorganisms9061238

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