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Iron in Translation: From the Beginning to the End

Departamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Catedrático Agustín Escardino 7, Paterna, 46980 Valencia, Spain
Departamento de Bioquímica y Biología Molecular, Universitat de València, Doctor Moliner 50, Burjassot, 46100 Valencia, Spain
Authors to whom correspondence should be addressed.
Academic Editors: Yoav Arava and Ayala Shiber
Microorganisms 2021, 9(5), 1058;
Received: 29 April 2021 / Revised: 10 May 2021 / Accepted: 11 May 2021 / Published: 13 May 2021
(This article belongs to the Special Issue Yeast: Translation Regulation and Localized Translation)
Iron is an essential element for all eukaryotes, since it acts as a cofactor for many enzymes involved in basic cellular functions, including translation. While the mammalian iron-regulatory protein/iron-responsive element (IRP/IRE) system arose as one of the first examples of translational regulation in higher eukaryotes, little is known about the contribution of iron itself to the different stages of eukaryotic translation. In the yeast Saccharomyces cerevisiae, iron deficiency provokes a global impairment of translation at the initiation step, which is mediated by the Gcn2-eIF2α pathway, while the post-transcriptional regulator Cth2 specifically represses the translation of a subgroup of iron-related transcripts. In addition, several steps of the translation process depend on iron-containing enzymes, including particular modifications of translation elongation factors and transfer RNAs (tRNAs), and translation termination by the ATP-binding cassette family member Rli1 (ABCE1 in humans) and the prolyl hydroxylase Tpa1. The influence of these modifications and their correlation with codon bias in the dynamic control of protein biosynthesis, mainly in response to stress, is emerging as an interesting focus of research. Taking S. cerevisiae as a model, we hereby discuss the relevance of iron in the control of global and specific translation steps. View Full-Text
Keywords: translation; tRNA modification; yeast; Saccharomyces cerevisiae; iron deficiency translation; tRNA modification; yeast; Saccharomyces cerevisiae; iron deficiency
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MDPI and ACS Style

Romero, A.M.; Martínez-Pastor, M.T.; Puig, S. Iron in Translation: From the Beginning to the End. Microorganisms 2021, 9, 1058.

AMA Style

Romero AM, Martínez-Pastor MT, Puig S. Iron in Translation: From the Beginning to the End. Microorganisms. 2021; 9(5):1058.

Chicago/Turabian Style

Romero, Antonia M.; Martínez-Pastor, María T.; Puig, Sergi. 2021. "Iron in Translation: From the Beginning to the End" Microorganisms 9, no. 5: 1058.

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