Next Article in Journal
Comparative Evaluation of Four Potent Neospora caninum Diagnostic Antigens Using Immunochromatographic Assay for Detection of Specific Antibody in Cattle
Previous Article in Journal
Soil Layers Matter: Vertical Stratification of Root-Associated Fungal Assemblages in Temperate Forests Reveals Differences in Habitat Colonization
 
 
Article

Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia

1
Department of Microbiology, Meiji Pharmaceutical University, Kiyose 204-8588, Japan
2
Research & Development Headquarters Self-Medication, Taisho Pharmaceutical Co., Ltd., Saitama 331-9530, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Roberto Di Marco
Microorganisms 2021, 9(10), 2132; https://doi.org/10.3390/microorganisms9102132
Received: 30 August 2021 / Revised: 1 October 2021 / Accepted: 8 October 2021 / Published: 11 October 2021
(This article belongs to the Section Medical Microbiology)
The skin microbiome and sebum may be associated with inflammation-related diseases of the scalp. To assess the pathogenesis and progression of androgenetic alopecia (AGA), we analyzed the composition of sebum and the bacterial and fungal microbiomes of the scalps of 118 Japanese male individuals with and without AGA, then discussed their roles in the pathogenesis of AGA. Sebum triglyceride and palmitic acid contents were higher in the AGA group than in the non-AGA group. Malassezia restricta, a lipophilic fungus that consumes palmitic acid, was abundant on the scalps of patients with AGA. Cutibacterium, Corynebacterium, and Staphylococcus were the most common genera in both groups, and patients with AGA exhibited scalp dysbiosis (increased abundance of Cutibacterium and decreased abundance of Corynebacterium). Our findings suggest that both sebum and the bacterial and fungal microbiomes of the scalp may be involved in the development of AGA. View Full-Text
Keywords: androgenetic alopecia; scalp; microbiome; sebum composition; Malassezia androgenetic alopecia; scalp; microbiome; sebum composition; Malassezia
Show Figures

Figure 1

MDPI and ACS Style

Suzuki, K.; Inoue, M.; Cho, O.; Mizutani, R.; Shimizu, Y.; Nagahama, T.; Sugita, T. Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia. Microorganisms 2021, 9, 2132. https://doi.org/10.3390/microorganisms9102132

AMA Style

Suzuki K, Inoue M, Cho O, Mizutani R, Shimizu Y, Nagahama T, Sugita T. Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia. Microorganisms. 2021; 9(10):2132. https://doi.org/10.3390/microorganisms9102132

Chicago/Turabian Style

Suzuki, Kazuhiro, Mizuna Inoue, Otomi Cho, Rumiko Mizutani, Yuri Shimizu, Tohru Nagahama, and Takashi Sugita. 2021. "Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia" Microorganisms 9, no. 10: 2132. https://doi.org/10.3390/microorganisms9102132

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop