Chronic Active Epstein–Barr Virus Infection: The Elucidation of the Pathophysiology and the Development of Therapeutic Methods
1
Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan
2
Department of Hematological Therapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo 113-8510, Japan
Microorganisms 2021, 9(1), 180; https://doi.org/10.3390/microorganisms9010180
Received: 25 December 2020
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Revised: 13 January 2021
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Accepted: 14 January 2021
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Published: 15 January 2021
(This article belongs to the Special Issue Pathogenic Role of Virus Infection in Head and Neck Tumors)
Chronic active Epstein–Barr virus infection (CAEBV) is a disease where Epstein–Barr virus (EBV)-infected T- or NK-cells are activated and proliferate clonally. The symptoms of this dual-faced disease include systemic inflammation and multiple organ failures caused by the invasion of infected cells: inflammation and neoplasm. At present, the only effective treatment strategy to eradicate EBV-infected cells is allogeneic stem cell transplantation. Lately, the investigation into the disease’s pathogenic mechanism and pathophysiology has been advancing. In this review, I will evaluate the new definition in the 2017 WHO classification, present the advancements in the study of CAEBV, and unfold the future direction.
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Keywords:
systemic chronic active Epstein–Barr virus infection; cutaneous chronic active Epstein–Barr virus infection; EBV-positive T-cell lymphoma of childhood; WHO classification
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MDPI and ACS Style
Arai, A. Chronic Active Epstein–Barr Virus Infection: The Elucidation of the Pathophysiology and the Development of Therapeutic Methods. Microorganisms 2021, 9, 180. https://doi.org/10.3390/microorganisms9010180
AMA Style
Arai A. Chronic Active Epstein–Barr Virus Infection: The Elucidation of the Pathophysiology and the Development of Therapeutic Methods. Microorganisms. 2021; 9(1):180. https://doi.org/10.3390/microorganisms9010180
Chicago/Turabian StyleArai, Ayako. 2021. "Chronic Active Epstein–Barr Virus Infection: The Elucidation of the Pathophysiology and the Development of Therapeutic Methods" Microorganisms 9, no. 1: 180. https://doi.org/10.3390/microorganisms9010180
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