Correlation between Exogenous Compounds and the Horizontal Transfer of Plasmid-Borne Antibiotic Resistance Genes
Abstract
:1. Introduction
2. Horizontal Transfer of Antibiotic Resistance Genes
3. Exogenous Compounds Promote Horizontal Genes Transfer
4. Exogenous Compounds Inhibit Plasmid Transfer
5. Conclusions and Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Compounds | Year | Species | Plasmid/ARGs | Mechanisms |
---|---|---|---|---|
Silver ions/nanoparticles | 2020 | E. coli → P. putida | RP4 | ROS generation, membrane damage and the SOS response. |
Triclosan | 2020 | Plasmid → E. coli | pUC19 | Triggers ROS over-production, damages cell membrane barrier, mediates the pilus capture of plasmid and the translocation of plasmid via cell membrane channels. |
Preservatives | 2020 | E. coli → E. coli | pCM194-Cm | Stimulates radical-induced RpoS regulon and SOS response, increases cell membrane permeability, and regulates conjugative transfer-related genes. |
Copper nanoparticles/ions | 2019 | E. coli → P. putida | RP4 | Over-production of ROS. |
Carbamazepine | 2019 | E. coli → E. coli; E. coli → P. putida; | -- | Increases ROS and the SOS response and enhances cell membrane permeability and pilus generation. |
CO2 | 2019 | E. coli → E. coli; E. coli → S. typhimurium; | RP4 | Reduces intercellular repulsion and increases PMF. |
Triclosan | 2018 | E. coli → E. coli; E. coli → P. putida; | RP4 | Promotes ROS generation and damages bacterial membrane, and causes increased expression of the SOS response regulatory genes. |
Disinfectants (free chlorine, chloramine, and hydrogen peroxide) | 2017 | E. coli → E. coli; E. coli → S. typhimurium; | -- | Intracellular ROS formation, SOS response, increases cell membrane permeability, and alters expressions of conjugation relevant genes. |
Polycyclic aromatic hydrocarbons (PAHs) | 2017 | intI1-positive bacterium Aerococcus sp. → intI1-negative bacterium Pseudoalteromonas sp. | intI1, sulI and aadA2 genes | -- |
Gentamicin | 2017 | E. coli → P. aeruginosa | RP4 | Inhibits quorum sensing. |
Ionic liquid ((BMIm)(PF6)) | 2015 | E. coil K12 → Salmonella spp.; E. coil K12 → microbacterium spp. | RP4 | Enhances cell membrane permeability. |
Ionic liquid ((BMIm)(PF6)) | 2014 | intI-positive bacteria to other bacterial strains | sulI and intI genes | Increases cell membrane permeability. |
Nanoalumina | 2012 | E. coli → Salmonella; E. coli → E. coli; G+ → G−; Enterococci → Enterococci | RP4 | Damages bacterial membranes, enhances the expression of conjugative genes and represses global regulatory factor genes. |
Compounds | Year | Species | Plasmid | ARGs | Mechanisms |
---|---|---|---|---|---|
COM-blockers (triclosan, hydrochloride and pimozide) | 2020 | S. pneumoniae → E. coli | -- | -- | Inhibits PMF, thereby preventing the export of a quorum-sensing CSP |
Azidothymidine | 2020 | E. coli → E. coli | Tet(X)-producing plasmids | tet(X3/X4) | -- |
Anti-HIV drugs (abacavir and azidothymidine) | 2020 | E. coli → E. coli K. pneumoniae → K. pneumoniae | ESBL-producing plasmid (pCT) and carbapenemase-producing plasmid (pKpQIL) | Extended spectrum β-lactamase and carbapenemase genes | -- |
Fe2O3@MoS2 | 2019 | E. coli → E. coli; E. coli → E. faecalis; E. faecalis → E. faecalis | RP4-7 | -- | Promotes the expression of global regulatory gene (trbA) and inhibits the expression of conjugative transfer genes |
Isothiocyanates | 2019 | E. coli → E. coli | pKM101 (IncN), TP114 (IncI2), pUB307 (IncP) and R7K (IncW) | -- | -- |
Flavophospholipol | 2019 | E. coli → E. coli; E. faecalis → E. faecalis | Self-transmissible plasmids carrying the βlactamase genes or vanA genes | Extended-spectrum β-lactamase and vanA genes | -- |
Molecules (105055 and 239852) | 2017 | E. coli → E. coli | pKM101 | -- | Targets the TraE protein |
Unsaturated fatty acids | 2016 | E. coli → E. coli | IncW, IncH, IncF IncI, IncL/M and IncX | -- | Targets type IV traffic ATPase TrwD |
Tanzawaic acids | 2016 | E. coli → E. coli | IncW and IncFII | -- | -- |
B8I-16, BAR-072, BAR-073 and UM-024 | 2016 | E. coli → E. coli | pKM101 | -- | Targets the TraE protein |
Peptidomimetic | 2016 | E. coli → E. coli | IncF plasmid | -- | Disrupts type IV secretion system |
Synthetic fatty acids | 2015 | Escherichia, Salmonella, Pseudomonas and Acinetobacter spp | IncF, IncW, IncH, IncI, IncL/M, and IncX plasmids | -- | -- |
Bisphosphonates | 2007 | E. coli → E. coli | F plasmid | -- | Inhibits the conjugative DNA relaxase |
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Liu, Y.; Tong, Z.; Shi, J.; Jia, Y.; Yang, K.; Wang, Z. Correlation between Exogenous Compounds and the Horizontal Transfer of Plasmid-Borne Antibiotic Resistance Genes. Microorganisms 2020, 8, 1211. https://doi.org/10.3390/microorganisms8081211
Liu Y, Tong Z, Shi J, Jia Y, Yang K, Wang Z. Correlation between Exogenous Compounds and the Horizontal Transfer of Plasmid-Borne Antibiotic Resistance Genes. Microorganisms. 2020; 8(8):1211. https://doi.org/10.3390/microorganisms8081211
Chicago/Turabian StyleLiu, Yuan, Ziwen Tong, Jingru Shi, Yuqian Jia, Kangni Yang, and Zhiqiang Wang. 2020. "Correlation between Exogenous Compounds and the Horizontal Transfer of Plasmid-Borne Antibiotic Resistance Genes" Microorganisms 8, no. 8: 1211. https://doi.org/10.3390/microorganisms8081211