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Article

Switching to Integrase Inhibitors Unlinked to Weight Increase in Perinatally HIV-Infected Young Adults and Adolescents: A 10-Year Observational Study

1
Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, 20122 Milan, Italy
2
Infectious Diseases Clinic, Department of Health Sciences (DiSSal), University of Genoa, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
3
Biostatistics Unit, Department of Health Sciences (DiSSal), University of Genoa, 16132 Genoa, Italy
4
Pediatric Infectious Disease Unit, ASST Fatebenefratelli-Sacco, University of Milan, 20157 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Microorganisms 2020, 8(6), 864; https://doi.org/10.3390/microorganisms8060864
Received: 24 April 2020 / Revised: 26 May 2020 / Accepted: 4 June 2020 / Published: 8 June 2020
(This article belongs to the Special Issue Present and Future Challenges of HIV Infection)
An unexpected increase in weight gain has recently been reported in the course of integrase strand transfer inhibitors (INSTI) treatment. The possibility of this effect in people who are perinatally infected with HIV (PHIV) and thus exposed to lifelong therapy needs to be explored. This is a retrospective multicenter case-control study. Adults with PHIV followed between 2010 and 2019 in two outpatient services in Northern Italy were included if they had at least two weight measures in two successive years of observation. Patients were considered as cases if they were switched to INSTI (INSTI group), or controls if they were never exposed to INSTI (non-INSTI group). The date of the switch in cases was considered to be the baseline (T0), while it was randomly selected in controls. Mixed effect models were used to assess the weight changes in INSTI and non-INSTI groups. A total of 66 participants, 50.0% women, 92.4% Caucasian, were included. Median follow-up was 9 years (range 2–10): 4 years (range 1–8) before and 3 (range 1–9) after-T0. Mean age at the last study visit was 27.3 (±4.8) years, and mean CD4+ T-cells were 820.8 (±323.6) cells/mm3. Forty-five patients were switched to INSTI during the study, while 21 remained in the non-INSTI group. The INSTI group experienced a mean increase (pre-post T0) in bodyweight of 0.28 kg/year (95% CI − 0.29; 0.85, p = 0.338), while in the non-INSTI group, the mean increase was 0.36 kg/year (95% CI − 0.47; 1.20, p = 0.391), without a significant difference between groups (p for interaction between time and treatment regimen = 0.868). Among patients on INSTI, the weight gain after T0 was higher than pre-T0, amounting to +0.28 kg/year (95% CI − 0.29; 0.85), although this difference did not reach significance (p = 0.337). PHIV switched to an INSTI-based regimen did not experience an excessive weight gain compared to those who were treated with a non-INSTI based regimen in our cohort. View Full-Text
Keywords: integrase strand transfer inhibitor; weight gain; HIV metabolic complication; perinatal HIV infection integrase strand transfer inhibitor; weight gain; HIV metabolic complication; perinatal HIV infection
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MDPI and ACS Style

Taramasso, L.; Di Biagio, A.; Bovis, F.; Forlanini, F.; Albani, E.; Papaioannu, R.; Giacomet, V. Switching to Integrase Inhibitors Unlinked to Weight Increase in Perinatally HIV-Infected Young Adults and Adolescents: A 10-Year Observational Study. Microorganisms 2020, 8, 864. https://doi.org/10.3390/microorganisms8060864

AMA Style

Taramasso L, Di Biagio A, Bovis F, Forlanini F, Albani E, Papaioannu R, Giacomet V. Switching to Integrase Inhibitors Unlinked to Weight Increase in Perinatally HIV-Infected Young Adults and Adolescents: A 10-Year Observational Study. Microorganisms. 2020; 8(6):864. https://doi.org/10.3390/microorganisms8060864

Chicago/Turabian Style

Taramasso, Lucia, Antonio Di Biagio, Francesca Bovis, Federica Forlanini, Elena Albani, Rebecka Papaioannu, and Vania Giacomet. 2020. "Switching to Integrase Inhibitors Unlinked to Weight Increase in Perinatally HIV-Infected Young Adults and Adolescents: A 10-Year Observational Study" Microorganisms 8, no. 6: 864. https://doi.org/10.3390/microorganisms8060864

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