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Open AccessCommunication

Salmonella Genomic Island 1 is Broadly Disseminated within Gammaproteobacteriaceae

1
The ithree institute, University of Technology Sydney, Ultimo, NSW 2007, Australia
2
Australian Centre for Genomic Epidemiological Microbiology, University of Technology Sydney, PO Box 123, Broadway, NSW 2007, Australia
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(2), 161; https://doi.org/10.3390/microorganisms8020161
Received: 6 January 2020 / Revised: 20 January 2020 / Accepted: 20 January 2020 / Published: 23 January 2020
(This article belongs to the Special Issue Bacterial Genomes and Evolution by Horizontal Gene Transfer (HGT))
Salmonella genomic island 1 (SGI1) is an integrative mobilisable element that plays an important role in the capture and spread of multiple drug resistance. To date, SGI1 has been found in clinical isolates of Salmonella enterica serovars, Proteus mirabilis, Morganella morganii, Acinetobacter baumannii, Providencia stuartii, Enterobacter spp, and recently in Escherichia coli. SGI1 preferentially targets the 3´-end of trmE, a conserved gene found in the Enterobacteriaceae and among members of the Gammaproteobacteria. It is, therefore, hypothesised that SGI1 and SGI1-related elements (SGI1-REs) may have been acquired by diverse bacterial genera. Here, Bitsliced Genomic Signature Indexes (BIGSI) was used to screen the NCBI Sequence Read Archive (SRA) for putative SGI1-REs in Gammaproteobacteria. Novel SGI-REs were identified in diverse genera including Cronobacter spp, Klebsiella spp, and Vibrio spp and in two additional isolates of Escherichia coli. An extensively drug-resistant human clonal lineage of Klebsiella pneumoniae carrying an SGI1-RE in the United Kingdom and an SGI1-RE that lacks a class 1 integron were also identified. These findings provide insight into the origins of this diverse family of clinically important genomic islands and expand the knowledge of the potential host range of SGI1-REs within the Gammaproteobacteria. View Full-Text
Keywords: Salmonella genomic island 1 (SGI1); antimicrobial resistance (AMR); Proteus genomic island (PGI); Vibrio genomic island (VGI); Klebsiella genomic island (KGI); genomics Salmonella genomic island 1 (SGI1); antimicrobial resistance (AMR); Proteus genomic island (PGI); Vibrio genomic island (VGI); Klebsiella genomic island (KGI); genomics
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MDPI and ACS Style

Cummins, M.L.; Hamidian, M.; Djordjevic, S.P. Salmonella Genomic Island 1 is Broadly Disseminated within Gammaproteobacteriaceae. Microorganisms 2020, 8, 161. https://doi.org/10.3390/microorganisms8020161

AMA Style

Cummins ML, Hamidian M, Djordjevic SP. Salmonella Genomic Island 1 is Broadly Disseminated within Gammaproteobacteriaceae. Microorganisms. 2020; 8(2):161. https://doi.org/10.3390/microorganisms8020161

Chicago/Turabian Style

Cummins, Max L.; Hamidian, Mohammad; Djordjevic, Steven P. 2020. "Salmonella Genomic Island 1 is Broadly Disseminated within Gammaproteobacteriaceae" Microorganisms 8, no. 2: 161. https://doi.org/10.3390/microorganisms8020161

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