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The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease

1
Faculty of Pharmacy, University of Ljubljana, SI-1000 Ljubljana, Slovenia
2
Department of Biotechnology, Jožef Stefan Institute, SI-1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(11), 1715; https://doi.org/10.3390/microorganisms8111715
Received: 16 September 2020 / Revised: 13 October 2020 / Accepted: 31 October 2020 / Published: 1 November 2020
(This article belongs to the Special Issue Lactic Acid Bacteria and Bifidobacteria and Their Application)
The two most important bacterial phyla in the gastrointestinal tract, Firmicutes and Bacteroidetes, have gained much attention in recent years. The Firmicutes/Bacteroidetes (F/B) ratio is widely accepted to have an important influence in maintaining normal intestinal homeostasis. Increased or decreased F/B ratio is regarded as dysbiosis, whereby the former is usually observed with obesity, and the latter with inflammatory bowel disease (IBD). Probiotics as live microorganisms can confer health benefits to the host when administered in adequate amounts. There is considerable evidence of their nutritional and immunosuppressive properties including reports that elucidate the association of probiotics with the F/B ratio, obesity, and IBD. Orally administered probiotics can contribute to the restoration of dysbiotic microbiota and to the prevention of obesity or IBD. However, as the effects of different probiotics on the F/B ratio differ, selecting the appropriate species or mixture is crucial. The most commonly tested probiotics for modifying the F/B ratio and treating obesity and IBD are from the genus Lactobacillus. In this paper, we review the effects of probiotics on the F/B ratio that lead to weight loss or immunosuppression. View Full-Text
Keywords: probiotics; Firmicutes; Bacteroidetes; dysbiosis; obesity; inflammation probiotics; Firmicutes; Bacteroidetes; dysbiosis; obesity; inflammation
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MDPI and ACS Style

Stojanov, S.; Berlec, A.; Štrukelj, B. The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease. Microorganisms 2020, 8, 1715. https://doi.org/10.3390/microorganisms8111715

AMA Style

Stojanov S, Berlec A, Štrukelj B. The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease. Microorganisms. 2020; 8(11):1715. https://doi.org/10.3390/microorganisms8111715

Chicago/Turabian Style

Stojanov, Spase, Aleš Berlec, and Borut Štrukelj. 2020. "The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease" Microorganisms 8, no. 11: 1715. https://doi.org/10.3390/microorganisms8111715

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