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Article

A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan

1
Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
2
National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki 852-8523, Japan
3
Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-0818, Japan
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(11), 1672; https://doi.org/10.3390/microorganisms8111672
Received: 5 October 2020 / Revised: 24 October 2020 / Accepted: 27 October 2020 / Published: 28 October 2020
(This article belongs to the Special Issue Tick-Borne Encephalitis)
Tick-borne encephalitis (TBE) is a zoonotic disease that usually presents as a moderate febrile illness followed by severe encephalitis, and various neurological symptoms are observed depending on the distinct central nervous system (CNS) regions affected by the TBE virus (TBEV) infection. In Japan, TBE incidence is increasing and TBEV distributions are reported in wide areas, specifically in Hokkaido. However, an extensive epidemiological survey regarding TBEV has not been conducted yet. In this study, we conducted a retrospective study of the prevalence of antibodies against TBEV in patients with neurological disorders and healthy populations in a TBEV-endemic area in Hokkaido. Among 2000 patients, three patients with inflammatory diseases in the CNS had TBEV-specific IgM antibodies and neutralizing antibodies. The other four patients diagnosed clinically with other neurological diseases were positive for TBEV-specific IgG and neutralizing antibodies, indicating previous TBEV infection. In a total of 246 healthy residents in a TBEV-endemic region, one resident had TBEV-specific antibodies. These results demonstrated undiagnosed TBEV infections in Japan. Further surveys are required to reveal the actual epidemiological risk of TBE and to consider preventive measures, such as a vaccine program, for the control of TBE in Japan. View Full-Text
Keywords: tick-borne encephalitis; tick; neurological disorder; epidemiology; zoonosis tick-borne encephalitis; tick; neurological disorder; epidemiology; zoonosis
MDPI and ACS Style

Yoshii, K.; Takahashi-Iwata, I.; Shirai, S.; Kobayashi, S.; Yabe, I.; Sasaki, H. A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan. Microorganisms 2020, 8, 1672. https://doi.org/10.3390/microorganisms8111672

AMA Style

Yoshii K, Takahashi-Iwata I, Shirai S, Kobayashi S, Yabe I, Sasaki H. A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan. Microorganisms. 2020; 8(11):1672. https://doi.org/10.3390/microorganisms8111672

Chicago/Turabian Style

Yoshii, Kentaro, Ikuko Takahashi-Iwata, Shinichi Shirai, Shintaro Kobayashi, Ichiro Yabe, and Hidenao Sasaki. 2020. "A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan" Microorganisms 8, no. 11: 1672. https://doi.org/10.3390/microorganisms8111672

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