The Anti-Rotaviral Activity of Low Molecular Weight and Non-Proteinaceous Substance from Bifidobacterium longum BORI Cell Extract
by
Yeo Ok Han 1,
Yunju Jeong 1,2,
Hyun Ju You 1,3,
Seockmo Ku 4
,
Geun Eog Ji 1,2 and
Myeong Soo Park 2,*
Yeo Ok Han 1,
Yunju Jeong 1,2,
Hyun Ju You 1,3,
Seockmo Ku 4,
Geun Eog Ji 1,2 and
Myeong Soo Park 2,*
1
Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea
2
Research Center, BIFIDO Co., Ltd., Hongcheon 25117, Korea
3
Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea
4
Fermentation Science Program, School of Agriculture, College of Basic and Applied Sciences, Middle Tennessee State University, Murfreesboro, TN 37132, USA
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(4), 108; https://doi.org/10.3390/microorganisms7040108
Received: 19 March 2019 / Revised: 21 April 2019 / Accepted: 22 April 2019 / Published: 23 April 2019
(This article belongs to the Special Issue Safety Aspects of Lactic Acid Bacteria)
Rotavirus infection is the most common diarrheal disease worldwide in children under five years of age, and it often results in death. In recent years, research on the relationship between rotavirus and probiotics has shown that probiotics are effective against diarrhea. A clinical trial has reported that Bifidobacterium longum BORI reduced diarrhea induced by rotavirus. The present work investigated the anti-rotaviral effect of B. longum BORI by cytopathic effect observation and real time cell analyses. Our study found that B. longum BORI showed strong anti-rotaviral effect when incubated with MA104 cells prior to viral infection, suggesting that the probiotic does in fact interfere with the interaction of viruses and host cells. It is believed that the efficacy is due to low-molecular weight and non-protein components derived from B. longum BORI. This discovery can help broaden the industrial application of B. longum BORI, which has been proven to be a safe and effective probiotic.
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Keywords:
rotavirus infection; Bifidobacterium longum BORI; probiotics; cytopathic effect; real time cell analysis
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MDPI and ACS Style
Han, Y.O.; Jeong, Y.; You, H.J.; Ku, S.; Ji, G.E.; Park, M.S. The Anti-Rotaviral Activity of Low Molecular Weight and Non-Proteinaceous Substance from Bifidobacterium longum BORI Cell Extract. Microorganisms 2019, 7, 108.
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