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Are Community Acquired Respiratory Viral Infections an Underestimated Burden in Hematology Patients?

1
Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Babes str., 400012 Cluj-Napoca, Romania
2
University of Agricultural Sciences and Veterinary Medicine, Calea Mănăștur 3-5, 400372 Cluj-Napoca, Romania
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Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Haţieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
4
Airway Disease Infection Section, National Heart Lung Institute, Imperial College London, London, UK MRC & Asthma UK Centre for Allergic Mechanisms of Asthma, Norfolk Place, W2 1PG London, UK
5
School of Medicine, Nanjing University, 22 Hankou Road, 210093 Nanjing, China
6
Department of Hematology, Ion Chiricuta Oncology Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
Microorganisms 2019, 7(11), 521; https://doi.org/10.3390/microorganisms7110521
Received: 8 October 2019 / Revised: 29 October 2019 / Accepted: 31 October 2019 / Published: 2 November 2019
(This article belongs to the Section Medical Microbiology)
Despite a plethora of studies demonstrating significant morbidity and mortality due to community-acquired respiratory viral (CRV) infections in intensively treated hematology patients, and despite the availability of evidence-based guidelines for the diagnosis and management of respiratory viral infections in this setting, there is no uniform inclusion of respiratory viral infection management in the clinical hematology routine. Nevertheless, timely diagnosis and systematic management of CRV infections in intensively treated hematology patients has a demonstrated potential to significantly improve outcome. We have briefly summarized the recently published data on CRV infection epidemiology, as well as guidelines on the diagnosis and management of CRV infections in patients intensively treated for hematological malignancies. We have also assessed available treatment options, as well as mentioned novel agents currently in development.
Keywords: respiratory viral infections; community respiratory viruses; hematological malignancy; stem cell transplantation; intensive chemotherapy respiratory viral infections; community respiratory viruses; hematological malignancy; stem cell transplantation; intensive chemotherapy
MDPI and ACS Style

Popescu, C.-M.; Ursache, A.L.; Feketea, G.; Bocsan, C.; Jimbu, L.; Mesaros, O.; Edwards, M.; Wang, H.; Berceanu, I.; Neaga, A.; Zdrenghea, M. Are Community Acquired Respiratory Viral Infections an Underestimated Burden in Hematology Patients? Microorganisms 2019, 7, 521.

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