Next Article in Journal
Bacterial Endophyte Colonization and Distribution within Plants
Next Article in Special Issue
Relationship among Phosphorus Circulation Activity, Bacterial Biomass, pH, and Mineral Concentration in Agricultural Soil
Previous Article in Journal
Combating Fusarium Infection Using Bacillus-Based Antimicrobials
Previous Article in Special Issue
Microbial Community Structure and Functions in Ethanol-Fed Sulfate Removal Bioreactors for Treatment of Mine Water
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessReview
Microorganisms 2017, 5(4), 76;

Biotechnological Applications of Microbial (Per)chlorate Reduction

Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
Energy Biosciences Institute, University of California, Berkeley, CA 94704, USA
Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Author to whom correspondence should be addressed.
Received: 5 October 2017 / Revised: 18 November 2017 / Accepted: 22 November 2017 / Published: 24 November 2017
(This article belongs to the Special Issue Microorganisms for Environmental and Industrial Applications)
Full-Text   |   PDF [2211 KB, uploaded 27 November 2017]   |  


While the microbial degradation of a chloroxyanion-based herbicide was first observed nearly ninety years ago, only recently have researchers elucidated the underlying mechanisms of perchlorate and chlorate [collectively, (per)chlorate] respiration. Although the obvious application of these metabolisms lies in the bioremediation and attenuation of (per)chlorate in contaminated environments, a diversity of alternative and innovative biotechnological applications has been proposed based on the unique metabolic abilities of dissimilatory (per)chlorate-reducing bacteria (DPRB). This is fueled in part by the unique ability of these organisms to generate molecular oxygen as a transient intermediate of the central pathway of (per)chlorate respiration. This ability, along with other novel aspects of the metabolism, have resulted in a wide and disparate range of potential biotechnological applications being proposed, including enzymatic perchlorate detection; gas gangrene therapy; enhanced xenobiotic bioremediation; oil reservoir bio-souring control; chemostat hygiene control; aeration enhancement in industrial bioreactors; and, biogenic oxygen production for planetary exploration. While previous reviews focus on the fundamental science of microbial (per)chlorate reduction (for example see Youngblut et al., 2016), here, we provide an overview of the emerging biotechnological applications of (per)chlorate respiration and the underlying organisms and enzymes to environmental and biotechnological industries. View Full-Text
Keywords: perchlorate; chlorate; microbial perchlorate reduction; perchlorate bioremediation; bio-souring control; bioreactor hygiene controls; aeration enhancement perchlorate; chlorate; microbial perchlorate reduction; perchlorate bioremediation; bio-souring control; bioreactor hygiene controls; aeration enhancement

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Wang, O.; Coates, J.D. Biotechnological Applications of Microbial (Per)chlorate Reduction. Microorganisms 2017, 5, 76.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Microorganisms EISSN 2076-2607 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top