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Microorganisms
Volume 12
Issue 8
10.3390/microorganisms12081712
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Article

Two-Year Study on the Intra-Individual Dynamics of Gut Microbiota and Short-Chain Fatty Acids Profiles in Healthy Adults

by
Anastasia Senina
1,
Maria Markelova
1,
Dilyara Khusnutdinova
1,
Maria Siniagina
1,
Olga Kupriyanova
1,2,
Gulnaz Synbulatova
1,
Airat Kayumov
1,
Eugenia Boulygina
1 and
Tatiana Grigoryeva
1,*
1
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia
2
Regional Research and Testing Center “Pharmexpert”, Kazan State Medical University, 420012 Kazan, Russia
*
Author to whom correspondence should be addressed.
Microorganisms 2024, 12(8), 1712; https://doi.org/10.3390/microorganisms12081712
Submission received: 25 July 2024 / Revised: 14 August 2024 / Accepted: 17 August 2024 / Published: 20 August 2024
(This article belongs to the Special Issue Advances in Host-Gut Microbiota)
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Abstract

While the gut microbiome has been intensively investigated for more than twenty years already, its role in various disorders remains to be unraveled. At the same time, questions about what changes in the gut microbiota can be considered as normal or pathological and whether communities are able to recover after exposure to negative factors (diseases, medications, environmental factors) are still unclear. Here, we describe changes in the gut microbiota composition and the content of short-chain fatty acids in adult healthy volunteers (n = 15) over a 24 month-period. Intraindividual variability in gut microbial composition was 40%, whereas the short chain fatty acids profile remained relatively stable (2-year variability 20%, inter-individual 26%). The changes tend to accumulate over time. Nevertheless, both short-term and long-term changes in the gut microbiome composition were significantly smaller within individuals than interindividual differences (two-year interindividual variability was 75%). Seasonal changes in gut microbiota were found more often in autumn and spring involving the content of minor representatives (less than 1.5% of the community in average) in the phyla Actinobacteriota, Firmicutes and Proteobacteria.
Keywords: gut microbiota; 16S rRNA; short chain fatty acids (SCFAs); healthy microbiota; temporal stability; seasonal changes; individual fingerprint gut microbiota; 16S rRNA; short chain fatty acids (SCFAs); healthy microbiota; temporal stability; seasonal changes; individual fingerprint

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MDPI and ACS Style

Senina, A.; Markelova, M.; Khusnutdinova, D.; Siniagina, M.; Kupriyanova, O.; Synbulatova, G.; Kayumov, A.; Boulygina, E.; Grigoryeva, T. Two-Year Study on the Intra-Individual Dynamics of Gut Microbiota and Short-Chain Fatty Acids Profiles in Healthy Adults. Microorganisms 2024, 12, 1712. https://doi.org/10.3390/microorganisms12081712

AMA Style

Senina A, Markelova M, Khusnutdinova D, Siniagina M, Kupriyanova O, Synbulatova G, Kayumov A, Boulygina E, Grigoryeva T. Two-Year Study on the Intra-Individual Dynamics of Gut Microbiota and Short-Chain Fatty Acids Profiles in Healthy Adults. Microorganisms. 2024; 12(8):1712. https://doi.org/10.3390/microorganisms12081712

Chicago/Turabian Style

Senina, Anastasia, Maria Markelova, Dilyara Khusnutdinova, Maria Siniagina, Olga Kupriyanova, Gulnaz Synbulatova, Airat Kayumov, Eugenia Boulygina, and Tatiana Grigoryeva. 2024. "Two-Year Study on the Intra-Individual Dynamics of Gut Microbiota and Short-Chain Fatty Acids Profiles in Healthy Adults" Microorganisms 12, no. 8: 1712. https://doi.org/10.3390/microorganisms12081712

APA Style

Senina, A., Markelova, M., Khusnutdinova, D., Siniagina, M., Kupriyanova, O., Synbulatova, G., Kayumov, A., Boulygina, E., & Grigoryeva, T. (2024). Two-Year Study on the Intra-Individual Dynamics of Gut Microbiota and Short-Chain Fatty Acids Profiles in Healthy Adults. Microorganisms, 12(8), 1712. https://doi.org/10.3390/microorganisms12081712

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