Next Article in Journal
Dermacentor reticulatus and Babesia canis in Bavaria (Germany)—A Georeferenced Field Study with Digital Habitat Characterization
Previous Article in Journal
Prevalence of the Puumala orthohantavirus Strains in the Pre-Kama Area of the Republic of Tatarstan, Russia
Article

Sequential Pathology of a Genotype XIII Newcastle Disease Virus from Bangladesh in Chickens on Experimental Infection

Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(7), 539; https://doi.org/10.3390/pathogens9070539
Received: 13 June 2020 / Revised: 2 July 2020 / Accepted: 3 July 2020 / Published: 6 July 2020
(This article belongs to the Section Animal Pathogens)
The sequential pathology of a genotype XIII Bangladeshi strain of Newcastle disease virus (NDV) was studied in 5-weeks old chickens. Layer chickens of ISA Brown breed were inoculated through the intranasal and intraocular routes with the BD-C161/2010 strain of NDV and examined at different times post-infection (pi). NDV-infected chickens showed depression at 3 days pi (dpi) followed by dropped wings, paralysis and death starting at 4 dpi. Lungs of infected chickens showed hemorrhagic lesions starting at 24 hours pi (hpi) that was followed by pallor and slight contraction by 2 to 3 dpi and subsequently developed into severe hemorrhagic pneumonia with mononuclear cell infiltration. Hemorrhagic and necrotizing lesions were found in different visceral organs including proventriculus, intestine, gut-associated lymphoid tissues, liver and kidneys starting at 3 dpi that progressed rapidly. Severe lymphoid depletion was observed in the thymus, spleen and bursa of Fabricius starting at 1–3 dpi followed by hemorrhages, necrosis, inflammation and atrophy at 4–5 dpi. In the brain, mild neuronal lesions such as focal to diffuse encephalitis with encephalomalacia was observed at 2–3 dpi and moderate and diffuse meningoencephalitis with encephalomalacia at advanced stages. In conclusion, the BD-C161/2010 strain of NDV produced lesions typical of velogenic viscerotropic pathotype of NDV. View Full-Text
Keywords: newcastle disease virus; genotype XIII; velogenic pathotype; lymphoid depletion; meningoencephalitis; Bangladesh newcastle disease virus; genotype XIII; velogenic pathotype; lymphoid depletion; meningoencephalitis; Bangladesh
Show Figures

Figure 1

MDPI and ACS Style

Kabiraj, C.K.; Mumu, T.T.; Chowdhury, E.H.; Islam, M.R.; Nooruzzaman, M. Sequential Pathology of a Genotype XIII Newcastle Disease Virus from Bangladesh in Chickens on Experimental Infection. Pathogens 2020, 9, 539. https://doi.org/10.3390/pathogens9070539

AMA Style

Kabiraj CK, Mumu TT, Chowdhury EH, Islam MR, Nooruzzaman M. Sequential Pathology of a Genotype XIII Newcastle Disease Virus from Bangladesh in Chickens on Experimental Infection. Pathogens. 2020; 9(7):539. https://doi.org/10.3390/pathogens9070539

Chicago/Turabian Style

Kabiraj, Congriev K., Tanjin T. Mumu, Emdadul H. Chowdhury, Mohammad R. Islam, and Mohammed Nooruzzaman. 2020. "Sequential Pathology of a Genotype XIII Newcastle Disease Virus from Bangladesh in Chickens on Experimental Infection" Pathogens 9, no. 7: 539. https://doi.org/10.3390/pathogens9070539

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop