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Distinct Signaling Pathways Between Human Macrophages and Primary Gingival Epithelial Cells by Aggregatibacter actinomycetemcomitans
Open AccessEditorial

Editorial Comments to the Special Issue: “Aggregaterbacter actinomycetemcomitans—Gram-Negative Bacterial Pathogen”

1
Department of Odontology, Umeå University, S-901 87 Umeå, Sweden
2
Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104-6030, USA
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(6), 441; https://doi.org/10.3390/pathogens9060441
Received: 29 May 2020 / Accepted: 2 June 2020 / Published: 4 June 2020
Aggregatibacter actinomycetemcomitans is a periodontal pathogen colonizing the oral cavity in many individuals of the human population. It is equipped with several potent virulence factors that can cause cell death and induce or evade the host inflammatory response. Both harmless and highly virulent genotypes of the bacterium have emerged because of the large genetic diversity within the species. The oral condition and age, as well as the geographic origin of the individual, influence the risk to be colonized by a virulent genotype of the bacterium. In the present editorial, the different genetic and virulence properties of A. actinomycetemcomitans will be addressed in relation to the publications in this Special Issue. View Full-Text
Keywords: Aggregatibacter actinomycetemcomitans; leukotoxin; cytolethal distending toxin; lipopolysaccharides; cytokine binding factors; horizontal gene transfer; outer membrane vesicles; biofilm; proteomics Aggregatibacter actinomycetemcomitans; leukotoxin; cytolethal distending toxin; lipopolysaccharides; cytokine binding factors; horizontal gene transfer; outer membrane vesicles; biofilm; proteomics
MDPI and ACS Style

Oscarsson, J.; DiRienzo, J.; Johansson, A. Editorial Comments to the Special Issue: “Aggregaterbacter actinomycetemcomitans—Gram-Negative Bacterial Pathogen”. Pathogens 2020, 9, 441.

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