Next Article in Journal
Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs
Previous Article in Journal
Paenibacillus alvei MP1 as a Producer of the Proteinaceous Compound with Activity against Important Human Pathogens, Including Staphylococcus aureus and Listeria monocytogenes
Open AccessCase Report

Escherichia coli Strains with Virulent Factors Typical for Uropathogens were Isolated from Sinuses from Patients with Chronic Rhinosinusitis—Case Report

1
Department of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdańsk University of Technology, 80-233 Gdańsk, Poland
2
Medical Center MML, 00-112 Warsaw, Poland
3
Nowicki Institute for Women’s Health Research (Now I for HeR), 114 Governors Way, Brentwood, TN 37027, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pathogens 2020, 9(5), 318; https://doi.org/10.3390/pathogens9050318
Received: 23 March 2020 / Revised: 21 April 2020 / Accepted: 23 April 2020 / Published: 25 April 2020
(This article belongs to the Special Issue Microbial Interactions during Infection)
Escherichia coli were isolated from three patients with chronic rhinosinusitis (CRS) by intraoperative sinus tissue biopsy. Taking into account the unusual replicative niche and previous treatment failures, it was decided to focus on the virulence and drug resistance of these bacteria. The strains turned out to be multi-sensitive, but the rich virulence factors profile of bacteria typical for phylogenetic group B2 deserved attention. Tests were carried out for the presence of 32 genes using the PCR method. Particularly noteworthy are the toxins Cnf-1, HlyA, Usp—an extensive iron uptake system (enterobactin, salmochelin, yersiniabactin and outer membrane hemin receptor ChuA)—SPATE autotransporters such as vat and pic, Ag43 autoaggregative protein—important for biofilm formation—and TosA/B which enhance the fitness of E.coli. All these virulence factors are identified predominantly in UPEC strains and provide a fitness advantage during colonization of the sinuses. Patients with CRS should be asked for past or present UTI. The specific virulence factors of E. coli that facilitate the colonization of the GI tract and urinary tract may also favor the colonization of a new ecological niche (sinuses) as a result of microbial imbalance or dysbiosis. View Full-Text
Keywords: biopsy; E.coli; virulence factors; UPEC; chronic rhinosinusitis biopsy; E.coli; virulence factors; UPEC; chronic rhinosinusitis
Show Figures

Figure 1

MDPI and ACS Style

Krawczyk, B.; Michalik, M.; Fordon, M.; Wysocka, M.; Samet, A.; Nowicki, B. Escherichia coli Strains with Virulent Factors Typical for Uropathogens were Isolated from Sinuses from Patients with Chronic Rhinosinusitis—Case Report. Pathogens 2020, 9, 318.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop