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Open AccessArticle

Pathogenicity and Genetic Characterization of Vietnamese Classical Swine Fever Virus: 2014–2018

1
Viral Disease Division, Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk 39660, Korea
2
College of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam
3
College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Korea
4
College of Veterinary Medicine, Seoul University, Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
*
Author to whom correspondence should be addressed.
These authors made an equal contribution to this work.
Pathogens 2020, 9(3), 169; https://doi.org/10.3390/pathogens9030169
Received: 31 January 2020 / Revised: 26 February 2020 / Accepted: 26 February 2020 / Published: 28 February 2020
(This article belongs to the Special Issue Classical Swine Fever)
Here, we examined the pathogenicity and genetic differences between classical swine fever viruses (CSFV) isolated on pig farms in North Vietnam from 2014–2018. Twenty CSFV strains from 16 pig farms were classified as genotype 2 (sub-genotypes 2.1b, 2.1c, and 2.2). The main sub-genotype, 2.1c, was classified phylogenetically as belonging to the same cluster as viruses isolated from the Guangdong region in South China. Strain HY58 (sub-genotype 2.1c), isolated from pigs in Vietnam, caused higher mortality (60%) than the Vietnamese ND20 strain (sub-genotype 2.2). The Vietnamese strain of sub-genotype 2.1b was estimated to have moderate virulence; indeed, genetic analysis revealed that it belongs to the same cluster as Korean CSFV sub-genotype 2.1b. Most CSFVs circulating in North Vietnam belong to sub-genotype 2.1c. Geographical proximity means that this genotype might continue to circulate in both North Vietnam and Southern China (Guangdong, Guangxi, and Hunan). View Full-Text
Keywords: CSFV; genotype; virulence; E2 gene; phylogenetic tree CSFV; genotype; virulence; E2 gene; phylogenetic tree
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Choe, S.; Le, V.P.; Shin, J.; Kim, J.-H.; Kim, K.-S.; Song, S.; Cha, R.M.; Park, G.-N.; Nguyen, T.L.; Hyun, B.-H.; Park, B.-K.; An, D.-J. Pathogenicity and Genetic Characterization of Vietnamese Classical Swine Fever Virus: 2014–2018. Pathogens 2020, 9, 169.

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