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Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2

Department of Microbiology and Immunology, Center for Human Immunology, The University of Western Ontario, London, ON N0M 2N0, Canada
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 51368, Iran
Robarts Research Institute, London, ON N6A 5K8, Canada
Author to whom correspondence should be addressed.
Pathogens 2020, 9(12), 1027;
Received: 10 November 2020 / Revised: 30 November 2020 / Accepted: 6 December 2020 / Published: 8 December 2020
(This article belongs to the Collection Immunological Responses and Immune Defense Mechanism)
The current coronavirus disease 2019 (COVID-19) pandemic, a disease caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), was first identified in December 2019 in China, and has led to thousands of mortalities globally each day. While the innate immune response serves as the first line of defense, viral clearance requires activation of adaptive immunity, which employs B and T cells to provide sanitizing immunity. SARS-CoV-2 has a potent arsenal of mechanisms used to counter this adaptive immune response through processes, such as T cells depletion and T cell exhaustion. These phenomena are most often observed in severe SARS-CoV-2 patients, pointing towards a link between T cell function and disease severity. Moreover, neutralizing antibody titers and memory B cell responses may be short lived in many SARS-CoV-2 patients, potentially exposing these patients to re-infection. In this review, we discuss our current understanding of B and T cells immune responses and activity in SARS-CoV-2 pathogenesis. View Full-Text
Keywords: COVID-19; SARS-CoV-2; adaptive immunity; B and T cell immune response COVID-19; SARS-CoV-2; adaptive immunity; B and T cell immune response
MDPI and ACS Style

Taefehshokr, N.; Taefehshokr, S.; Heit, B. Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2. Pathogens 2020, 9, 1027.

AMA Style

Taefehshokr N, Taefehshokr S, Heit B. Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2. Pathogens. 2020; 9(12):1027.

Chicago/Turabian Style

Taefehshokr, Nima, Sina Taefehshokr, and Bryan Heit. 2020. "Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2" Pathogens 9, no. 12: 1027.

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