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Sepsis, Phages, and COVID-19

1
Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, Poland
2
Phage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, Poland
3
Department of Clinical Immunology, Infant Jesus Clinical Hospital, 02-006 Warsaw, Poland
4
Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, 02-006 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(10), 844; https://doi.org/10.3390/pathogens9100844
Received: 21 August 2020 / Revised: 9 October 2020 / Accepted: 13 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue Host-Pathogen Interactions and Phage Therapy)
Phage therapy has emerged as a potential novel treatment of sepsis for which no decisive progress has been achieved thus far. Obviously, phages can help eradicate local bacterial infection and bacteremia that may occur in a syndrome. For example, phages may be helpful in correcting excessive inflammatory responses and aberrant immunity that occur in sepsis. Data from animal studies strongly suggest that phages may indeed be an efficient means of therapy for experimentally induced sepsis. In recent years, a number of reports have appeared describing the successful treatment of patients with sepsis. Moreover, novel data on the anti-viral potential of phages may be interpreted as suggesting that phages could be used as an adjunct therapy in severe COVID-19. Thus, clinical trials assessing the value of phage therapy in sepsis, including viral sepsis, are urgently needed. View Full-Text
Keywords: sepsis; phage; COVID-19 sepsis; phage; COVID-19
MDPI and ACS Style

Górski, A.; Borysowski, J.; Międzybrodzki, R. Sepsis, Phages, and COVID-19. Pathogens 2020, 9, 844.

AMA Style

Górski A, Borysowski J, Międzybrodzki R. Sepsis, Phages, and COVID-19. Pathogens. 2020; 9(10):844.

Chicago/Turabian Style

Górski, Andrzej; Borysowski, Jan; Międzybrodzki, Ryszard. 2020. "Sepsis, Phages, and COVID-19" Pathogens 9, no. 10: 844.

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