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Communication

Evaluation of the Results of Group B Streptococcus Screening by MALDI-TOF MS among Pregnant Women in a Hungarian Hospital

1
Institute of Clinical Microbiology, Albert Szent-Györgyi Clinical Center, University of Szeged, 6725 Szeged, Hungary
2
Bioanalytical Development, Bruker Daltonik GmbH, 28359 Bremen, Germany
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(1), 1; https://doi.org/10.3390/pathogens9010001
Received: 2 December 2019 / Revised: 13 December 2019 / Accepted: 15 December 2019 / Published: 18 December 2019
(This article belongs to the Section Human Pathogens)
Pregnant women colonized by Streptococcus agalactiae, or group B streptococcus (GBS), are at an increased risk of premature delivery and stillbirth, and their neonates can be endangered by the development of an invasive GBS disease. In this study, the results of the GBS screening among pregnant women performed between 2012 and 2018 (n = 19267) are presented. For the GBS positive samples, the antibiotic susceptibility of the isolated strains was also tested (n = 3554). During the examined period, the colonization rate varied between 17.4% and 19.8%. The overall rate of erythromycin and clindamycin resistance in the GBS positive samples was 34.9% and 34.6%, respectively. The frequency of the erythromycin and clindamycin resistant strains showed an increasing tendency. An analysis of the MALDI-TOF MS spectra of 260 GBS isolates revealed that 46.5% of them belonged to either the ST-1 or the ST-17 sequence types, indicating a high prevalence of these potentially invasive GBS strains in our region. More than half of the strains identified as ST-1 (52.1%) proved to be resistant to erythromycin and clindamycin. View Full-Text
Keywords: Streptococcus agalactiae; antibiotic susceptibility; ST-1; ST-17; MALDI-TOF MS Streptococcus agalactiae; antibiotic susceptibility; ST-1; ST-17; MALDI-TOF MS
MDPI and ACS Style

Ábrók, M.; Tigyi, P.; Kostrzewa, M.; Burián, K.; Deák, J. Evaluation of the Results of Group B Streptococcus Screening by MALDI-TOF MS among Pregnant Women in a Hungarian Hospital. Pathogens 2020, 9, 1. https://doi.org/10.3390/pathogens9010001

AMA Style

Ábrók M, Tigyi P, Kostrzewa M, Burián K, Deák J. Evaluation of the Results of Group B Streptococcus Screening by MALDI-TOF MS among Pregnant Women in a Hungarian Hospital. Pathogens. 2020; 9(1):1. https://doi.org/10.3390/pathogens9010001

Chicago/Turabian Style

Ábrók, Marianna, Petra Tigyi, Markus Kostrzewa, Katalin Burián, and Judit Deák. 2020. "Evaluation of the Results of Group B Streptococcus Screening by MALDI-TOF MS among Pregnant Women in a Hungarian Hospital" Pathogens 9, no. 1: 1. https://doi.org/10.3390/pathogens9010001

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