Next Article in Journal / Special Issue
Characterization of Three Ocular Clinical Isolates of P. aeruginosa: Viability, Biofilm Formation, Adherence, Infectivity, and Effects of Glycyrrhizin
Previous Article in Journal
Six Years (2011–2016) of Mandatory Nationwide Bovine Viral Diarrhea Control in Germany—A Success Story
Article Menu

Export Article

Open AccessFeature PaperReview
Pathogens 2017, 6(4), 51; https://doi.org/10.3390/pathogens6040051

An Update on the Sociomicrobiology of Quorum Sensing in Gram-Negative Biofilm Development

1
Department of Microbiology, University of Washington School of Medicine, Box 357735, 1959 NE Pacific Street, Seattle, WA 98195-7242, USA
2
School of Life Sciences, University of Nevada, Las Vegas Box MS 454004 4505 S. Maryland Parkway, Las Vegas, NV 89154, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 12 October 2017 / Accepted: 19 October 2017 / Published: 21 October 2017
(This article belongs to the Special Issue Signaling Systems in Pseudomonas aeruginosa Biofilm)
Full-Text   |   PDF [603 KB, uploaded 21 October 2017]   |  

Abstract

Bacteria are social creatures that are able to interact and coordinate behaviors with each other in a multitude of ways. The study of such group behaviors in microbes was coined “sociomicrobiology” in 2005. Two such group behaviors in bacteria are quorum sensing (QS) and biofilm formation. At a very basic level, QS is the ability to sense bacterial density via cell-to-cell signaling using self-produced signals called autoinducers, and biofilms are aggregates of cells that are attached to one another via a self-produced, extracellular matrix. Since cells in biofilm aggregates are in close proximity, biofilms represent an ecologically relevant environment for QS. While QS is known to affect biofilm formation in both Gram-negative and Gram-positive species, in this review, we will focus exclusively on Gram-negative bacteria, with an emphasis on Pseudomonas aeruginosa. We will begin by describing QS systems in P. aeruginosa and how they affect P. aeruginosa biofilm formation. We then expand our review to other Gram-negative bacteria and conclude with interesting questions with regard to the effect of biofilms on QS. View Full-Text
Keywords: sociomicrobiology; quorum sensing; biofilm; signaling sociomicrobiology; quorum sensing; biofilm; signaling
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Passos da Silva, D.; Schofield, M.C.; Parsek, M.R.; Tseng, B.S. An Update on the Sociomicrobiology of Quorum Sensing in Gram-Negative Biofilm Development. Pathogens 2017, 6, 51.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top