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An Update on the Sociomicrobiology of Quorum Sensing in Gram-Negative Biofilm Development

1
Department of Microbiology, University of Washington School of Medicine, Box 357735, 1959 NE Pacific Street, Seattle, WA 98195-7242, USA
2
School of Life Sciences, University of Nevada, Las Vegas Box MS 454004 4505 S. Maryland Parkway, Las Vegas, NV 89154, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Pathogens 2017, 6(4), 51; https://doi.org/10.3390/pathogens6040051
Received: 19 September 2017 / Revised: 12 October 2017 / Accepted: 19 October 2017 / Published: 21 October 2017
(This article belongs to the Special Issue Signaling Systems in Pseudomonas aeruginosa Biofilm)
Bacteria are social creatures that are able to interact and coordinate behaviors with each other in a multitude of ways. The study of such group behaviors in microbes was coined “sociomicrobiology” in 2005. Two such group behaviors in bacteria are quorum sensing (QS) and biofilm formation. At a very basic level, QS is the ability to sense bacterial density via cell-to-cell signaling using self-produced signals called autoinducers, and biofilms are aggregates of cells that are attached to one another via a self-produced, extracellular matrix. Since cells in biofilm aggregates are in close proximity, biofilms represent an ecologically relevant environment for QS. While QS is known to affect biofilm formation in both Gram-negative and Gram-positive species, in this review, we will focus exclusively on Gram-negative bacteria, with an emphasis on Pseudomonas aeruginosa. We will begin by describing QS systems in P. aeruginosa and how they affect P. aeruginosa biofilm formation. We then expand our review to other Gram-negative bacteria and conclude with interesting questions with regard to the effect of biofilms on QS. View Full-Text
Keywords: sociomicrobiology; quorum sensing; biofilm; signaling sociomicrobiology; quorum sensing; biofilm; signaling
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Passos da Silva, D.; Schofield, M.C.; Parsek, M.R.; Tseng, B.S. An Update on the Sociomicrobiology of Quorum Sensing in Gram-Negative Biofilm Development. Pathogens 2017, 6, 51.

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