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Urinary Tract Infection Molecular Mechanisms and Clinical Translation
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A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli

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Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstr. 30, München 81675, Germany
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Institute of Human Virology, Departments of Medicine, and Microbiology and Immunology, University of Maryland, School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA
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Department of Pathology, Case Western Reserve University, 2103 Cornell Rd, Cleveland, OH 44106, USA
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Department of Microbiology, Immunology and Glycobiology (MIG), Institute of Laboratory Medicine, Lund University, 221 00 Lund, Sweden
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Institute of Medical Microbiology and Hygiene, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Lawrence S. Young
Pathogens 2016, 5(1), 25; https://doi.org/10.3390/pathogens5010025
Received: 11 September 2015 / Revised: 23 February 2016 / Accepted: 25 February 2016 / Published: 29 February 2016
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters. View Full-Text
Keywords: bacterial pathogens; Toll-like receptors; TIR-containing proteins; TIR-domain structure bacterial pathogens; Toll-like receptors; TIR-containing proteins; TIR-domain structure
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Waldhuber, A.; Snyder, G.A.; Römmler, F.; Cirl, C.; Müller, T.; Xiao, T.S.; Svanborg, C.; Miethke, T. A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli. Pathogens 2016, 5, 25.

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